1. Reduced Acetylated Histone H4 is Associated With Promoter Methylation of the Fragile Histidine Triad Gene in Resected Esophageal Squamous Cell Carcinoma 
Ching Tzao, MD, PhD, Guang-Huan Sun, MD, PhD, Ho-Jui Tung, PhD, Han-Shui Hsu, MD, Wen-Hu Hsu, MD, Yi-Ching Wang, PhD, Yeung-Leung Cheng, MD, PhD, Shih-Chun Lee, MD 
The Annals of Thoracic Surgery 
Volume 82, Issue 2, Pages (August 2006)
DOI: /j.athoracsur
Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

2. Fig 1
Kaplan-Meier survival curve with log-rank test for 60 patients after resection for esophageal squamous cell carcinoma. Comparison of survival between patients with normal (dotted line) and aberrant (solid line)expression of fragile histidine triad (Fhit) protein and acetylated histone H4 is shown in (A) and (B), respectively. The 95% confidence intervals for median survival in groups of normal and aberrant Fhit expression were 25 to 33 and 9 to 31, respectively, and in normal and aberrant H4 groups, 28 to 30 and 9 to 31, respectively.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

3. Fig 2
Representative results of promoter methylation for fragile histidine triad (FHIT) gene. Primer sets used for amplification were designated as U for the unmethylated product and M for methylated genes; N represents normal mucosa sample and T represents tumor sample. Normal mucosa from patients (pt.) 1 and 2 showed only unmethylated FHIT, whereas tumor samples from these 2 patients also showed methylated FHIT (bp = base pair.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions