1. Interreg-IPA Cross-border Cooperation Programme Romania-Serbia
10 noiembrie Timșoara, România
Interreg-IPA Cross-border Cooperation Programme Romania-Serbia
Male microchimerism in the human female brain
where it comes from and what it does
Sanja Kalaba
February 2019
Employment promotion and basic services strengthening for an inclusive growth

2. INTRODUCTION Microchimerism- beneficial or adverse effects
10 noiembrie Timșoara, România
INTRODUCTION
Microchimerism- beneficial or adverse effects
Real-time quantitative PCR detects and quantifies male DNA in multiple brain regions of women
AD more prevalent in parous then in nulliparous
Higher number of pregnancies correlates with a younger age of AD onset

3. Subjects and specimens
26 deceased women without neurological disease and 33 women with AD
Age of death ranged from 32 to 101
Age of AD onset in those who had it ranged between 64 and 93 years, 77 median
Frontal lobe, parietal lobe, temporal lobe, occipital lobe, cingulate gyrus, hippocampus, amygdala, caudate, putamen, globus pallidus, thalamus, medulla, pons, cerebellum and spinal cord

4. STATISTICS
Association was reported as an odds ratio (OR) along with p value to indicate significance
Rate ratio - RR of 0.30 could be interpreted to say that the rate of Mc detection in subjects with AD was 70% lower than the rate of Mc detection in subjects without neurological disease

6. RESULTS
Mc Prevalence and Concentration According to Brain Regions
Prevalence and Concentration of Male Mc in Human Brain: Women without Neurologic Disease or with AD
Prevalence and Concentration of Male Mc in Brain Regions Affected by AD

8. The origin of male Mc in female brain is:
from pregnancy with a male fetus
from an abortion or a miscarriage
from a recognized or vanished male twin, an older male sibling
or through non-irradiated blood transfusion