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Filipin staining of marginal gyrus of cerebral cortex in NPC cats

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Presentation on theme: "Filipin staining of marginal gyrus of cerebral cortex in NPC cats"— Presentation transcript:

1 Fig. 6. Filipin staining of marginal gyrus of cerebral cortex in NPC cats.
Filipin staining of marginal gyrus of cerebral cortex in NPC cats. (A and B) Untreated 24-week-old NPC cats (B) showed storage of cholesterol (visualized as white cytoplasmic labeling within cells) in the marginal gyrus of the cerebral cortex, and no cholesterol storage was observed in healthy control animals (A). (C) Cats receiving HPβCD (1000 mg/kg SC) showed no reduction in cholesterol staining. (D) Cats receiving HPβCD (8000 mg/kg SC) showed substantially less cholesterol staining than did untreated NPC cats. Indeed, the example shown is from a 37-week-old cat that had received SC HPβCD until 24 weeks of age, at which time it was discontinued. (E and H) Cats (24 weeks old) receiving 30 mg of IC HPβCD or greater presymptomatically showed the greatest amelioration of the cholesterol storage defect. In contrast, treatment of NPC cats with 3.8 mg of IC HPβCD (G) or 120 mg of IC HPβCD administered postsymptomatically (F) revealed little effect on stored cholesterol at 24 weeks of age, whereas both 30 and 120 mg of HPβCD administered presymptomatically resulted in substantial reductions in cholesterol storage. Scale bar, 100 μm. Charles H. Vite et al., Sci Transl Med 2015;7:276ra26 Copyright © 2015, American Association for the Advancement of Science

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