1. CD160 on CD8+ T cells is required for optimal clearance of L
CD160 on CD8+ T cells is required for optimal clearance of L. monocytogenes.
CD160 on CD8+ T cells is required for optimal clearance of L. monocytogenes. (A) Schematic of experiment designed to assess function of CD160 on CD8+ T cells during oral L. monocytogenes infection. WT or CD160−/− naive CD8+ CD8+ T cell were transferred into RAG−/− recipients, infected with 2 × 109L. monocytogenes orally on the following day, and analyzed for bacterial burden and morbidity. (B) Survival of RAG−/− recipients receiving 3 × 106 WT (blue, n = 20) or CD160−/− (red, n = 19) naive CD8+ T cells and infected with 2 × 109L. monocytogenes orally. (C) Weight curve of WT (blue, n = 13) and CD160−/− (red, n = 14) littermates infected with 2 × 109L. monocytogenes orally. (D) Bacterial burden in spleen, small intestine, and colon from WT (blue circles, n = 11–12) and CD160−/− (red circles, n = 12) littermates on day 7 after oral infection with 2 × 109L. monocytogenes. Data are pooled from four independent experiments in (B)–(D). Data are represented as means ± SEM. Significance was assessed using log-rank (Mantel–Cox) test in (B), Student t test in (C), and Mann–Whitney nonparametric test in (D). *p < 0.05.
Catherine L. Tan et al. ImmunoHorizons 2018;2:
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