Presentation is loading. Please wait.

Presentation is loading. Please wait.

Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets.

Published byEthan Johnston Modified over 5 years ago

Similar presentations

Presentation on theme: "Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets."— Presentation transcript:

1 Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. MISTRG mice infected with YU-2 were sacrificed 5 or 12–20 wk p.i., and splenocytes were analyzed for differentiation and PD-1 expression. (A) Definition of T cell differentiation subsets. (B) Frequency of TN (blue), TEMRA (orange), TCM (pink), and TEM (gray) in CD4+ and CD8+ T cell subsets in the spleen during acute infection (upper panel) (MISTRG HIV−, n = 7; HIV+, n = 6) and chronic infection (lower panel) (MISTRG HIV−, n = 6, HIV+, n = 6). Median fluorescent intensity of PD-1 in uninfected and infected MISTRG mice on CD4+ (C) and CD8+ (D) T cell subsets in acute (upper panels) and chronic (lower panels) HIV infection. Data are mean ± SEM. *p < 0.05, **p < 0.01, two-tailed Mann–Whitney U test. Sandra Ivic et al. ImmunoHorizons 2017;1: Copyright © 2017 The Authors

Download ppt "Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets."

Similar presentations

High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.

High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.
Volume 42, Issue 2, Pages (February 2015)

Volume 42, Issue 2, Pages (February 2015)
Volume 45, Issue 5, Pages (November 2016)

Volume 45, Issue 5, Pages (November 2016)
B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition. B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition.

B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition. B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition.
by Juan C. Rodríguez-Alba, Miguel E

by Juan C. Rodríguez-Alba, Miguel E
IL-21 induces the expression of CX3CL1 in the muscle in EAM

IL-21 induces the expression of CX3CL1 in the muscle in EAM
miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation

miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation
PD-1 deficiency promotes the development of splenic GCs in male mice, and MR1 dissolves GCs in both genders. PD-1 deficiency promotes the development of.

PD-1 deficiency promotes the development of splenic GCs in male mice, and MR1 dissolves GCs in both genders. PD-1 deficiency promotes the development of.
Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG.

Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG.
Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.

Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.
TIGIT expression in naive T cells is accelerated by coculture with si-tolerant T cells at an early-stimulation stage. TIGIT expression in naive T cells.

TIGIT expression in naive T cells is accelerated by coculture with si-tolerant T cells at an early-stimulation stage. TIGIT expression in naive T cells.
Smaller T cell zone FRC areas in aged spleens.

Smaller T cell zone FRC areas in aged spleens.
FIP200 deficiency alters mitochondria activation and ROS production in T cells. FIP200 deficiency alters mitochondria activation and ROS production in.

FIP200 deficiency alters mitochondria activation and ROS production in T cells. FIP200 deficiency alters mitochondria activation and ROS production in.
DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.

DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.
Specific depletion of TFH and LCMV-specific CD4 T cells.

Specific depletion of TFH and LCMV-specific CD4 T cells.
CD8α+ DC-deficient mice are highly susceptible to Lm infection in the absence of CD169+ macrophages. CD8α+ DC-deficient mice are highly susceptible to.

CD8α+ DC-deficient mice are highly susceptible to Lm infection in the absence of CD169+ macrophages. CD8α+ DC-deficient mice are highly susceptible to.
Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Analogously.

Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Analogously.
Loss of pathogen-specific T cell memory is due to the absence of Runx2 in CD8+ T cells. Loss of pathogen-specific T cell memory is due to the absence of.

Loss of pathogen-specific T cell memory is due to the absence of Runx2 in CD8+ T cells. Loss of pathogen-specific T cell memory is due to the absence of.
Volume 41, Issue 1, Pages (July 2014)

Volume 41, Issue 1, Pages (July 2014)
GM-CSF–producing γδT cells are involved in the development of EAM

GM-CSF–producing γδT cells are involved in the development of EAM

Similar presentations

Ads by Google