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Fig. 4. CIZ1 reduces the impact of injury to the heart.

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Presentation on theme: "Fig. 4. CIZ1 reduces the impact of injury to the heart."— Presentation transcript:

1 Fig. 4. CIZ1 reduces the impact of injury to the heart.
CIZ1 reduces the impact of injury to the heart. (A) 16-week-old WT and Tg mice were subjected to coronary artery ligation. At 20 weeks ejection fraction was significantly better in Tg mice. (B) Representative haematoxylin and eosin-stained sections of ligated hearts at 20 weeks. Magnified images show border zone between healthy (pink) and damaged myocardium, which appears blue due to increased NM density. Border zone is depicted by the white dotted line. Scale bar=200 µm. (C) Hearts of ligated Tg mice at 20 weeks exhibited marginally increased replication index, while CM:NM ratio was not different (n= nuclei, 7-10 images/mouse, three mice/group). (D) Representative images of EdU-positive nuclei (red) in WT and Tg hearts. Nuclei, blue; cell membrane, green. Scale bar=20 μm. Data represented as mean± s.e.m. Sumia A. Bageghni et al. Biology Open 2017;6:92-99 © Published by The Company of Biologists Ltd

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