1. Lecture 7c 25 October 2010

2. ADEK
ABSORPTION AND TRANSPORT
CARRIERS FOR BOTH
LIPOPROTEINS IN THE BLOOD

3. FUNCTIONAL FOODS
VARIOUSLY RICH IN
A RANGE OF VITAMINS BUT
HAVE NOT
BEEN SHOWN TO BE AS EFFECTIVE
AS SUPPLEMENTS THEMSELVES
WHY? CONCENTRATION/ISOLATION AND
POSSIBLE INTERFERENCE FACTORS

4. VITAMINS AS NUTRACEUTICALS
SUPPLEMENTATION ONLY IF DIET DOES
NOT SUPPLY ENOUGH OR HAVE SECONDARY
NUTRIENT DEFICIENCIES THAT DIET WILL
NOT OVERCOME
E.G. -VITAMIN K
ELDERLY-LOW DIETARY INTAKE OF VITAMIN K-
GREEN LEAFY VEGGIES DEFICIT
ELDERLY-ANTIBIOTIC THERAPY OFTEN
DEPLETES VITAMIN K PRODUCING BACTERIA

5. VITAMINS AS NUTRACEUTICALS CONTINUED
REQUIRED IF
SUPPLEMENTS APPARENTLY HELP WITH A PARTICULAR DISEASE
HOWEVER!-TOXICITY- ESPECIALLY WITH FAT SOLUBLE VITAMINS

6. VITAMINS AS NUTRACEUTICALS CONTINUED
HEART DISEASE
BETA-CAROTENE, VITAMIN E ARE
ANTIOXIDANTS
LDL’S CONTENT OF BETA-CAROTENE
AND VITAMIN E DICTATE OXIDATION OF
LDL
VITAMIN E- HIGH (NON-TOXIC) DOSES
GIVE DECREASED PLATELET FUNCTION

7. VITAMINS AS NUTRACEUTICALS CONTINUED
DIABETES
BETA-CAROTENE, VITAMIN E ARE DEPLETED IN DIABETES AND THIS IS BELIEVED TO ENHANCE LOW DENSITY LIPOPROTEIN OXIDATION WHICH ENCOURAGES ATHEROSCLEROSIS

8. VITAMINS AS NUTRACEUTICALS CONTINUED
CANCER
OXIDATION OF E.G. DNA
CONTRIBUTES TO CANCER
AND BETA-CAROTENE, VITAMIN E COMBATS THIS OXIDATION

9. VITAMINS AS NUTRACEUTICALS CONTINUED
OSTEOPOROSIS
VITAMIN D AND CALCIUM SUPPLEMENTS OFTEN GIVEN TO ELDERLY TO OVERCOME HORMONALLY INDUCED BONE LOSS

10. VITAMINS AS NUTRACEUTICALS CONTINUED
COELIAC DISEASE
IRRITATION OF SMALL INTESTINE WITH GLUTEN
(A PROTEIN PART OF SOME GRAINS) –IMMUNE RESPONSE-INFLAMMATION-MALABSORPTION
SOLUTIONS
A)ELIMINATE –WHEAT, OATS, BARLEY AND RYE
ALL OF WHICH CONTAIN GLUTEN
B) ADEK- SUPPLEMENT UNTIL HEAL
(VIA GLUTEN FREE AND/OR DRUGS)

11. VITAMIN A-IMPORTANT FOR SKIN AND IMMUNE FUNCTION
VITAMINS AS NUTRACEUTICALS CONTINUED
BURN PATIENTS
REGULAR DIET A PROBLEM
VITAMIN A-IMPORTANT FOR SKIN
AND IMMUNE FUNCTION

12. ANTIOXIDANT –BETA CAROTENE AND VITAMIN E HYPOTHESIZED TO COMBAT
VITAMINS AS NUTRACEUTICALS CONTINUED
SMOKERS
ANTIOXIDANT –BETA CAROTENE
AND VITAMIN E
HYPOTHESIZED TO COMBAT
OXIDISATION AGENTS FOUND IN
SMOKE

13. VITAMINS BETA-CAROTENE AND E IF NOT SUFFICIENT IN DIET-
VITAMINS AS NUTRACEUTICALS CONTINUED
PULMONARY DISEASE
VITAMINS BETA-CAROTENE AND E IF NOT
SUFFICIENT IN DIET-
ANTIOXIDANT ROLE

14. VITAMINS AS NUTRACEUTICALS CONTINUED
CYSTIC FIBROSIS
FAT SOLUBLE VITAMINS INADEQUATELY
ABSORBED
VITAMIN ADEK SUPPLEMENTATION VIA
INTRAVENOUS IF NECESSARY (PANCREATIC FUNCTION IS NOT ABLE TO WORK IN THIS DISEASE)

15. WHAT IS NEW IN FAT SOLUBLE VITAMIN
RESEARCH ?
VITAMIN D INTAKE MAY REDUCE
BREAST CANCER RISK