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Figure 2 C5B3 prevented AQP4-IgG–mediated CDC without affecting AQP4-IgG binding to AQP4 C5B3 prevented AQP4-IgG–mediated CDC without affecting AQP4-IgG.

Published byElisabeth Norton Modified over 5 years ago

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Presentation on theme: "Figure 2 C5B3 prevented AQP4-IgG–mediated CDC without affecting AQP4-IgG binding to AQP4 C5B3 prevented AQP4-IgG–mediated CDC without affecting AQP4-IgG."— Presentation transcript:

1 Figure 2 C5B3 prevented AQP4-IgG–mediated CDC without affecting AQP4-IgG binding to AQP4
C5B3 prevented AQP4-IgG–mediated CDC without affecting AQP4-IgG binding to AQP4 (A) After incubation with 10% serumNMOSD and 2.5% hC with or without C5B3, C3A6, and C5B35, we measured CHO cells cytotoxicity with LIVE/DEAD staining. (B) The percentage of dead cells from the experiments shown in Fig A. (C.a) CDC in M23-AQP4–overexpressing CHO cells incubated with 2.5% hC and different concentrations of serumNMOSD and C5B3. (C.b) CDC in M23-AQP4–overexpressing CHO cells incubated with 10% serumNMOSD and different concentrations of hC and C5B3. (D) We fixed the CHO cells and incubated them with 10% serumNMOSD with and without 800 μg/mL of C5B3 for immunostaining of AQP4 (red) and human IgG (green). The scale bar size for both A and D stains are all 200 μm. ***p < AQP4 = aquaporin-4; CDC = complement-dependent cytotoxicity; hC = human complement; IgG = immunoglobulin G. Wenli Zhu et al. Neurol Neuroimmunol Neuroinflamm 2019;6:e561 Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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