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The discovery of IgE Journal of Allergy and Clinical Immunology

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1 The discovery of IgE Journal of Allergy and Clinical Immunology
S.G.O. Johansson, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 137, Issue 6, Pages (June 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Professors Kimishige and Teruko Ishizaka.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Immunoelectrophoresis of serum ND (bottom) and a normal serum (top) using a mixture of antibodies to IgG, IgA, IgD, IgM, and kappa and lambda light chains (central channel). Note the black in the agar just left of the hole in the agar where serum ND was added. This indicates a high protein concentration, which does not fit with the very weak precipitate. The clear precipitate at the left end is free light chains.4 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Hans Bennich (left) and S. G. O. Johansson (right) in 1967.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Schematic drawing of blocking with IgND and the specific binding of reagin to mast cell and basophil receptors. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Serum IgND levels in patients with allergic and nonallergic asthma.8 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig 6 Principles of the RAST.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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