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Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions  Shelley F. Stone, PhD, Claire Cotterell,

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Presentation on theme: "Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions  Shelley F. Stone, PhD, Claire Cotterell,"— Presentation transcript:

1 Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions  Shelley F. Stone, PhD, Claire Cotterell, BSc (Hons), Geoffrey K. Isbister, MBBS, MD, FACEM, Anna Holdgate, MBBS, MMED, FACEM, Simon G.A. Brown, MBBS, PhD, FACEM  Journal of Allergy and Clinical Immunology  Volume 124, Issue 4, Pages e4 (October 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Lowess best fit curves to demonstrate the relationship between interval from reaction onset and mediator concentrations for patients with elevated levels of each mediator. A, MCT and histamine. B, IL-6 and IL-10. C, TNFRI. D, IL-2. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Line plots for individual results showing the full spread of values between interval from reaction onset and mediator concentrations for patients with elevated levels of mast cell tryptase (MCT), histamine, Interleukin (IL)-6, IL-10, Tumor Necrosis Factor Receptor I (TNFRI) and IL-2. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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