1. Madeira, Teixeira, Sa-Correia, Oliveira TCBB Volumn 7(1) 2010
Indentification of Regulatory Modules in Time Series Gene Expression Data
Madeira, Teixeira, Sa-Correia, Oliveira
TCBB Volumn 7(1) 2010

2. Introduction
Given a set of genes (rows) for a serious of event (column), biclustering identifies a subset of genes and events that have the same behaviour.
Biclustering is NP-Hard.
In time series data, one can assume the “event” have to be contiguous columns.

3. Process
Data discretization, transform data from expression to discrete values (up, down, no change)
Identify maximal biclusters.
Filter biclusters base on statistical significance.
Filter base on overlap

4. Data Discretization

5. Statistical Significance & Similarity

6. Generated Data

7. Yeast Data

8. Up Regulation

9. Down Regulation