1. Accepted for the Global Startup Program 2019 of the
A portable device for
therapeutic hypothermia
and temperature management
Contact:
Fabian Temme
An Investment that saves millions of lives.

2. Key Facts
Finance Planning
Medical Cooling had raised 3 grants of together € for
the published research
The main patent is transferred from the University Hospital of Hamburg Eppendorf Germany to the founder Fabian Temme and leaves the PCT process on March 9th 2019 (Link)
The team includes renown and experienced doctors, lawyers
and engineers
The path to the market is defined with a established supplier
The financial need to get there is a 3 Million € investment
The estimated post invest valuation is 10 Million €

3. The Guidelines Airway and breathing Circulation Control temperature
After a Successful Reanimation.
Return of spontaneous circulation and comatose
Airway and breathing
J.P. Nolan et al. / Resuscitation 95 (2015)
Maintain SpO %
Insert advanced airway
Waveform capnography
Ventilate lungs to normocapina
Circulation
1-2 lead ECG
Obtain reliable intravenous access
Aim for SBP > 100 mmHg
Fluid (crystalloid) – restore normovolaemia
Intra-arterial blood pressure
monitoring
Consider vasopressure/ inotrope to maintain SBP
Immediate Treatment
Control temperature
Constant temperature 32ºC - 36ºC
Sedation, control shivering

4. The earlier the cooling starts, the more damage can be prevented!
How does it work?
Chill brain
Slow down
metabolism
Reduce Oxygen
Consumption
Less brain
damage
To 36°C (96,8°F)
The earlier the cooling starts, the more damage can be prevented!

5. The Competition Requirements: Portable User Friendly Non-Invasive
bulky
impractical
invasive
expensive
In Clinic:
Zoll (Link)
Arctic Sun (Link)
Stryker (Link)
Portable:
BrainCool (Link)
Quickcools (Link)
Em Cools (Link)
Qool (Link)
Requirements:
Portable
User Friendly
Non-Invasive
Affordable

6. Heating with ambient air
The Solution
Simple Portfolio
2l Liquid
oxygen
Heating with ambient air
Setting mix for ideal
output temperature
Providing patient
oxygen of -23°C (-9 °F)

7. Scientific Publications
Our Scientific Results in Humans are Published
time
 Lung cooling works as most blood flows to the brain.
Let’s use it practical!
The method is
internationally accepted and awarded.

8. Adapting to Feedback Most paramedics didn't like the
idea of carrying more devices!
➔ We replaced the common
ventilator
➔ We integrated the vacuum
pump and ECG Defibrillator
Our Solution
Result:
➔ Two hands free!

9. Opportunities in Telemedicine
Video Stream (MD, poison information) conference mode possible
Black Box function (video or audio)
Mission feedback (time to treatment, time from arrival to departure, possible alternative solutions, treatment and target hospitals
Database to look-up (pharmacy information, diseases, etc…)
Access to digital patient folder
and information
Treatment question tree and treatment protocol
Suggestions of experts to contact
Dose calculation for pharmaceuticals
Voice controlled protocolling
The suggestion of treatment/examination based on AI prediction on how the patient develops
Suggestion of a clinic for the patient
and booking resources there
Complementary cameras and screens
in the ambulance
Video tutorials, especially for
rare treatments
Diagnostic camera (temperature cam for stroke diagnosis)

10. Our Achievements Demcon B.V. Very positive Feedback The Supplier
Through the recommenda-
tion of Dräger, we gained
an experienced partner as
Supplier.
Very positive Feedback
Positive feedback on
congresses, especially from doctors and paramedics as potential buyers.
The Supplier
The Customers
Drägerwerk AG
& Co. KGaA
We have an agreement
with Dräger that they will
not enter the Hypothermia market without us.
Working Prototype
The technology has
successfully accomplished
tests and is available for
live demonstration.
The Market Leader
The Technology

11. Business Model + Market Size
We provide the manufacturer and refilling companies with the license and collect a margin of each
sold refill and product.
ambulances
in the USA
Multiplier 8 estimates the world market compared
to the US size.
Market Share
$5.900
$18
20%
Marginal income per device
Marginal income per
oxygen refill $ $ $
marginal income p.a.
marginal income p.a.
Total income p.a.

12. Our Team Medical and Business Advisor MD MBA Matthias Glawe
Specialist for
CAD and
industrial 3D
Printing
Dipl.-Ing.
Roman Schmidt
Legal Advisor
Dr. law
Matthias Schulz
Paramedic mechanical engineer
leader
Fabian Temme
CEO
Medical Advisor MD
Stephan Kranz
Mathematician,
Tax Advisor
Dipl.-Math CRM
Armin Kaup
Ownership: 90% 5% 5%

13. Patent regionalization
Timeline to ROI
Presenting FDA
Certified Product
Return
of Investment
Investment
January
2019
March
2019
November
2019
2020
2023
Patent regionalization
CE Certification for
further markets

14. Use of your Investment Cost Income
We spend the investment for the first 1000 medical ventilators.
Cost
(in $1000)
Each
Sum
Serial Production
+ FDA
3 000
Sales Cost
+ Wages
1 000
Patent
5 000
Production 6
6 000
Shipment
0,1
100
6,1
6 100
Cost at all
11 100
Each
Sum
(in $1000)
3 000
1 000
5 000
Sales 12
12 000
Fix
Income
Variable
Result: $

15. Thank you! Your Investment benefits everyone!
Employer
 higher chance to return to work
Insurance
 contributor instead of just costs
Society
 taxpayer instead of foster
Patient
 less neurological damage  survives more likely
Investors
 high long-term return
Family
 fit not fostering
Contact:
Fabian Temme