1. Collagen accumulation is reduced with UK-396082.
Collagen accumulation is reduced with UK Following SNx, animals were culled at day 60 or day 35; kidneys were recovered, quartered, and fixed in neutral buffered formalin and stained with Masson’s trichrome to assess kidney fibrosis. Representative staining in the tubulointerstitium (top panel, A) and glomeruli (bottom panel, B). Sham-operated animals (left, upper and lower) and untreated SNx animals analyzed at day 35 (middle upper) and day 60 (right upper). UK (60 mg/kg per day)–treated animals analyzed on day 60; sham-treated from day 14 (left, lower) and SNx from day 35 (middle, lower) and day 14 (right, lower). Glomeruli are at ×400 magnification; tubulointerstitium at ×200 magnification.
John M. Atkinson et al. JASN 2015;26:
©2015 by American Society of Nephrology