Presentation is loading. Please wait.

Presentation is loading. Please wait.

Thomas B. Casale, MDa, I. Leonard Bernstein, MDb, William W

Published byClaude Kelly Modified over 5 years ago

Similar presentations

Presentation on theme: "Thomas B. Casale, MDa, I. Leonard Bernstein, MDb, William W"— Presentation transcript:

1 Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis 
Thomas B. Casale, MDa, I.Leonard Bernstein, MDb, William W. Busse, MDc, Craig F. LaForce, MDd, David G. Tinkelman, MDe, Randall R. Stoltz, MDf, Robert J. Dockhorn, MDg, James Reimann, PhDh, John Q. Su, PhDh, Robert B. Fick, MDh, Daniel C. Adelman, MDh  Journal of Allergy and Clinical Immunology  Volume 100, Issue 1, Pages (July 1997) DOI: /S (97) Copyright © 1997 Mosby, Inc. Terms and Conditions

2 Fig. 1 Geometric means of total rhuMAb-E25 by treatment group. Times are 5 minutes before dose; total rhuMAb-E25 has lower limit of quantification of 16 ng/ml, indicated by the faint dotted line. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

3 Fig. 2 Geometric means of free serum IgE by treatment group. Times are 5 minutes before dose; free IgE has limits of quantification of 10 ng/ml and 165 ng/ml. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

4 Fig. 3 Geometric means of serum total IgE (A) and ragweed-specific total IgE (B) by treatment group. Times are 5 minutes before dose. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

5 Fig. 3 Geometric means of serum total IgE (A) and ragweed-specific total IgE (B) by treatment group. Times are 5 minutes before dose. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

6 Fig. 4 A, Steady-state (SS) free IgE against steady-state total E25/total IgE ratio in treated patients. Steady-state concentrations are geometric means of predose values over days 42, 56, 70, and 84. B, Steady-state free IgE against dose/baseline IgE in dosed patients. Steady-state free IgE is geometric mean of predose values over days 42, 56, 70, and 84. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

7 Fig. 4 A, Steady-state (SS) free IgE against steady-state total E25/total IgE ratio in treated patients. Steady-state concentrations are geometric means of predose values over days 42, 56, 70, and 84. B, Steady-state free IgE against dose/baseline IgE in dosed patients. Steady-state free IgE is geometric mean of predose values over days 42, 56, 70, and 84. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

8 Fig. 5 Mean daily eye and nose symptom scores by study days.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

9 Fig. 6 Mean (± SEM) number of days rescue medication was used by treatment group. Plac., Placebo. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

10 Fig. 7 Weekly total symptom score by baseline ragweed-specific total IgE (all treatment groups combined). Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

11 Fig. 8 Weekly total symptom score by free IgE level (all treatment groups combined). Free IgE is geometric mean of predose values on days 14, 28, 42, 56, and 70. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

Download ppt "Thomas B. Casale, MDa, I. Leonard Bernstein, MDb, William W"

Similar presentations

Efficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane- beclomethasone extrafine inhalation aerosol), in asthma Jennifer.

Efficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane- beclomethasone extrafine inhalation aerosol), in asthma Jennifer.
Double-blind placebo-controlled study of the efficacy of oral terfenadine in the treatment of chronic fatigue syndrome  Paul Steinberg, MDa, Bruce E.

Double-blind placebo-controlled study of the efficacy of oral terfenadine in the treatment of chronic fatigue syndrome  Paul Steinberg, MDa, Bruce E.
Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy  Monica B. Arvidsson, MD, Olle.

Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy  Monica B. Arvidsson, MD, Olle.
Kiwi fruit allergy: A new birch pollen–associated food allergy

Kiwi fruit allergy: A new birch pollen–associated food allergy
F.Estelle R. Simons, MDa, Bruce M. Prenner, MDb, Albert Finn, MDc 

F.Estelle R. Simons, MDa, Bruce M. Prenner, MDb, Albert Finn, MDc 
A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis.

A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis.
Ulrich Wahn, MDa. ‡, Eli O. Meltzer, MDb. ‡, Albert F. Finn, MDc

Ulrich Wahn, MDa. ‡, Eli O. Meltzer, MDb. ‡, Albert F. Finn, MDc
Zafirlukast improves asthma symptoms and quality of life in patients with moderate reversible airflow obstruction  Robert A. Nathan, MDa, Jonathan A.

Zafirlukast improves asthma symptoms and quality of life in patients with moderate reversible airflow obstruction  Robert A. Nathan, MDa, Jonathan A.
Quantitative IgE antibody assays in allergic diseases

Quantitative IgE antibody assays in allergic diseases
Kiwi fruit allergy: A new birch pollen–associated food allergy

Kiwi fruit allergy: A new birch pollen–associated food allergy
A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children  Mark Boguniewicz, MDa, Virginia C. Fiedler,

A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children  Mark Boguniewicz, MDa, Virginia C. Fiedler,
Richard L. ZuWallack, MD a,b, James P

Richard L. ZuWallack, MD a,b, James P
Fluticasone furoate nasal spray: A single treatment option for the symptoms of seasonal allergic rhinitis  Harold B. Kaiser, MD, Robert M. Naclerio, MD,

Fluticasone furoate nasal spray: A single treatment option for the symptoms of seasonal allergic rhinitis  Harold B. Kaiser, MD, Robert M. Naclerio, MD,
Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults  Peter S. Creticos, MD, Jennifer Maloney,

Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults  Peter S. Creticos, MD, Jennifer Maloney,
Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma  Patrick Booms, MSca, David.

Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma  Patrick Booms, MSca, David.
Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis 

Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis 
The effect of omalizumab on nasal allergic inflammation

The effect of omalizumab on nasal allergic inflammation
Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis  Paul H. Ratner,

Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis  Paul H. Ratner,
Badrul A. Chowdhury, MD, PhD 

Badrul A. Chowdhury, MD, PhD 
Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis  James.

Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis  James.

Similar presentations

Ads by Google