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Loss of AMPKα1 Expression Is Associated with Poor Survival in Melanoma Patients
Madhuri Bhandaru, Magdalena Martinka, Gang Li, Anand Rotte Journal of Investigative Dermatology Volume 134, Issue 6, Pages (June 2014) DOI: /jid Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 AMPKα1 expression in melanoma. (a–f) Representative images of AMPKα1 immunohistochemical staining in human melanocytic lesions (bar = 100 μm in upper panels and 25 μm in lower panels). (a, d) Dysplastic nevi with low (IRS, 0–4) and (b, e) primary melanoma and (c, f) metastatic melanoma with high (IRS, 6–12) AMPKα1 staining. (g) AMPKα1 staining is significantly increased from dysplastic nevi (DN) to primary melanoma (PM) and decreased from primary melanoma to metastatic melanoma (MM) by the Kruskal–Wallis test. *P<0.05, **P< (h) Percentage of strong AMPKα1 staining is significantly increased from dysplastic nevi to primary melanoma and decreased from primary melanoma to metastatic melanoma by χ2-test. *P<0.05, **P< White filled bars represent low, and black filled bars represent high AMPKα1 staining. Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions
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