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Tuure Kinnunen, MD, Kalle Jutila, BM, William W

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Presentation on theme: "Tuure Kinnunen, MD, Kalle Jutila, BM, William W"— Presentation transcript:

1 Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy 
Tuure Kinnunen, MD, Kalle Jutila, BM, William W. Kwok, PhD, Marja Rytkönen-Nissinen, PhD, Anu Immonen, MSc, Soili Saarelainen, MSc, Ale Närvänen, PhD, Antti Taivainen, MD, PhD, Tuomas Virtanen, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 119, Issue 4, Pages (April 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Detection of peptide-specific T cells with MHC class II tetramers and CFSE dye dilution. Tetramer staining was performed on day 8 (A) and on day 15 (B) after stimulation with peptide-pulsed DCs. Representative results are shown for subject A-3. The percentages of divided tetramer-positive cells are indicated. The DR0401/HA tetramer was used as a control for staining. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Proliferative and cytokine responses of p –induced and pN135D-induced long-term TCLs. A, The proliferative responses of the TCLs are expressed as Δcpm (mean of stimulated wells − mean of unstimulated wells). The amounts of IFN-γ (B), IL-4 (C), and IL-10 (D) produced were detected in the supernatants. The peptide concentration used for stimulation was 50 μmol/L. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Different patterns of T-cell cross-reactivity: the homologous peptide is not recognized (A); the homologous peptide is recognized with a similar avidity (B) or with higher avidity than the peptide used for induction (C). All 3 TCLs were obtained from subject A-5 on stimulation with the peptide analog pN135D. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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