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Comparison of Outcomes after Peripheral Blood Haploidentical versus Matched Unrelated Donor Allogeneic Hematopoietic Cell Transplantation in Patients.

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Presentation on theme: "Comparison of Outcomes after Peripheral Blood Haploidentical versus Matched Unrelated Donor Allogeneic Hematopoietic Cell Transplantation in Patients."— Presentation transcript:

1 Comparison of Outcomes after Peripheral Blood Haploidentical versus Matched Unrelated Donor Allogeneic Hematopoietic Cell Transplantation in Patients with Acute Myeloid Leukemia: A Retrospective Single-Center Review  Armin Rashidi, John F. DiPersio, Peter Westervelt, Ravi Vij, Mark A. Schroeder, Amanda F. Cashen, Todd A. Fehniger, Rizwan Romee  Biology of Blood and Marrow Transplantation  Volume 22, Issue 9, Pages (September 2016) DOI: /j.bbmt Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Transplant outcomes in univariate analysis. (A) OS, (B) CIR and NRM, and cumulative incidence of aGVHD (C) grades II to IV and (D) grades III to IV are shown. These outcomes were not significantly different between the groups undergoing haploidentical versus MUD transplantation. See text for further details. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Cumulative incidence of National Institutes of Health–defined moderate to severe cGVHD requiring systemic immunosuppressive therapy and time to platelet and neutrophil recovery. The cumulative incidence of moderate/severe cGvHD was not different between the groups in univariate (A) or multivariate (D) analysis. Time to recovery of neutrophils and platelets was significantly shorter with MUD versus haploidentical HCT in both univariate (B and C) and multivariate (E and F) analysis. Adjusted curves were created using the mean value of the covariates in cumulative risk regression. See text for further details. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 OS, relapse, and aGVHD grades II to IV and III to IV in multivariate analysis. (A) OS, (B) CIR, and cumulative incidence of aGVHD (C) grades II to IV and (D) grades III to IV after adjustment for potential confounders are shown. These outcomes were not different between the groups undergoing haploidentical versus MUD HCT. Adjusted curves are drawn using the mean value of the covariates in Cox and cumulative incidence regression. See text for further details. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions


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