1. Mitoprotection as a strategy to prevent chondrocyte death and cartilage degeneration following mechanical injury 
M.L. Delco, E.D. Bonnevie, H.H. Szeto, L.J. Bonassar, L.A. Fortier 
Osteoarthritis and Cartilage 
Volume 24, Pages S500-S501 (April 2016)
DOI: /j.joca
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2. Figure 1. SS-31 prevents Impact-induced chondrocyte death
Figure 1. SS-31 prevents Impact-induced chondrocyte death. A) Control and (B,C) impacted cartilage stained for live (green)/dead (red) cells and imaged at 24 hr. C) SS-31 treatment 1 hr after injury. D) Cell death in impacted cartilage treated at 0 or 1 hr is equivalent to un-injured controls.
Osteoarthritis and Cartilage  , S500-S501DOI: ( /j.joca )
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3. Figure 2. SS-31 prevents cell membrane damage after cartilage Injury
Figure 2. SS-31 prevents cell membrane damage after cartilage Injury. Cartilage explants (n = 18) were impacted then incubated tor 7 days with or without SS-31. LDH activity was measured m cartilage conditioned media every 24 hr. Data is expressed as cumulative LDH activity over the culture period. *p < 0.05.
Osteoarthritis and Cartilage  , S500-S501DOI: ( /j.joca )
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4. Figure 3. SS-31 prevents cartilage matrix degradation after Injury
Figure 3. SS-31 prevents cartilage matrix degradation after Injury. Cartilage explants (n = 18) were impacted then incubated with or without SS-31. DMMB assay on cartilage conditioned media revealed A) GAG loss increased in impacted samples by 96 hr post-impact. B) Treatment at 0, 1 or 6 hr after impact decreased GAG loss at 96 hr. *p < 0.05.
Osteoarthritis and Cartilage  , S500-S501DOI: ( /j.joca )
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