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Incidence and Risk Factors for Early Hepatotoxicity and Its Impact on Survival in Patients with Myelofibrosis Undergoing Allogeneic Hematopoietic Cell.

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Presentation on theme: "Incidence and Risk Factors for Early Hepatotoxicity and Its Impact on Survival in Patients with Myelofibrosis Undergoing Allogeneic Hematopoietic Cell."— Presentation transcript:

1 Incidence and Risk Factors for Early Hepatotoxicity and Its Impact on Survival in Patients with Myelofibrosis Undergoing Allogeneic Hematopoietic Cell Transplantation  Kit Man Wong, Eshetu G. Atenafu, Dennis Kim, John Kuruvilla, Jeffrey H. Lipton, Hans Messner, Vikas Gupta  Biology of Blood and Marrow Transplantation  Volume 18, Issue 10, Pages (October 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Levels of AST (A), bilirubin (B), and albumin (C) at preconditioning, on the day of stem cell infusion, and at peak (or nadir for albumin) within the first 6 weeks after HCT. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Peak AST, bilirubin, and VOD in the MF group (A-C) and the MDS control group (D-F). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Impact of hyperbilirubinemia during the first 6 weeks post-HCT on 12-month OS (A) and NRM (B) in the MF group. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions


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