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Central Nervous System Complications after Allogeneic Hematopoietic Stem Cell Transplantation: Incidence, Manifestations, and Clinical Significance  Deborah.

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Presentation on theme: "Central Nervous System Complications after Allogeneic Hematopoietic Stem Cell Transplantation: Incidence, Manifestations, and Clinical Significance  Deborah."— Presentation transcript:

1 Central Nervous System Complications after Allogeneic Hematopoietic Stem Cell Transplantation: Incidence, Manifestations, and Clinical Significance  Deborah Siegal, Anne Keller, Wei Xu, Sandeep Bhuta, Dong Hwan Kim, John Kuruvilla, Jeffrey H. Lipton, Hans Messner, Vikas Gupta  Biology of Blood and Marrow Transplantation  Volume 13, Issue 11, Pages (November 2007) DOI: /j.bbmt Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 FLAIR axial images of brain show mild (A), moderate (B), and severe (C and D) forms of PRES corresponding with severity grading of 1, 2, and 3, respectively. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 The cumulative incidences of all CNS complications and PRES at days 30, 100, 180, and 365 were 9%, 18%, 20%, and 23%, and 4%, 6%, 7%, and 7%, respectively. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Kaplan-Meier plots of overall survival in patients with and without CNS complications (within 100 days posttransplant) and PRES. In comparison to their counterparts, survival at 1-year was significantly reduced in patients who developed CNS complications in the first 100 days posttransplant (28% versus 72%, P < .0001) (A), and PRES (27% versus 67%, P < .0001) (B). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions


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