1. For Large Scale Purification
CombiFlash Rf Torrent
For Large Scale
Purification

2. CombiFlash Rf Torrent Capabilities
Up to 1 L/min at 100 psi
300g purifications in an hour unattended
Automatic solvent level sensing
Customize for different laboratory needs
All external tubing for easy loading
Collect known compounds using Time Windows
Compact design

3. Pumping System Level sensing on inlet and waste
Makes it a walk away large scale system
Pumps precisely from 0 to 100%
Up to 1L/min accurately
Up to 100psi consistently
Accurately delivers DCM and MeOH
Solvent can be located on the floor
Up to 100 psi
Large tubing creates minimal system backpressure
Custom inlets for variety of sources

4. Binary Gradient 2 Solvent inlet
B solvent auto prime for accurate gradients
50ml/min to 1 L/min
80 grams up to 3 kg columns purification
80 gram useful for method development and scale up
Rapid equilibration function
Fast air purge for column disposal

5. Customizable to Meet any Purification Need

6. Solvent Inlet Options Stainless steel braided*
5 (standard), 9 ft length
Grounded flow path
Pressurized solvent reservoirs*
Custom connection
Quick Connects
*Ability to have level sensing

7. Stainless Steel Braided

8. Remote Solvent Source

9. Pressurized Solvent Reservoirs
With Solvent Level Sensing

10. Optional Solvent Caps 100 mm 83B Available for both inlet and outlet
Customize for your container

11. Injection Option 1 Solid load cartridges
Cartridges available in 4 sizes
25, 65, 260, and 750 gram
Available empty and prepacked
Prepacked with silica, Celite or C18
Bulk silicas also available
Use cartridges as a guard column to extend the life of reusable columns

12. Injection Option 2 Liquid Load pump Load manually with a syringe
Pull directly from a sample container
Utilize an empty cartridge as a funnel, pull from the cartridge and load onto the column
Load manually with a syringe

13. Automatic Operation Injection valve enables true walk- away automation
Automatically equilibrates, loads the sample and purifies
Post run - air purge, and clean the valve to ensure no cross contamination

14. Automatic Self Cleaning Injection Valve
All external tubing
Easy to access and clean
Automatic wash sequence
Wash injection valve with strong solvent after run
Prevents buildup in valve
Automatic operation
“Start and walk away”
Rapid auto air purge

15. Detector Options Select from either internal UV or UV-Vis PDA detector
Peak collection via slope, threshold or time windows
Perform All-Wavelength Collection
Ability to detect small impurities in the sample
Alternatively, connect to an external detector
Teledyne Isco Model 340CF ELSD available
December software release will add Spectral Capabilities
December software release will add MS support/control

16. Torrent Collection Option 1
Foxy R2 High Flow Fraction Collector with RFID rack identification technology
Chain up to 4 collectors together
Collect in mm test tubes or 450 ml bottles
Use funnel rack to collect unlimited quantities in any container
Collect based on Volume with triggers from detected Threshold, Slope and/or Time Windows

17. RFID Test Tubes Racks Funnel Rack (36)
Greatest Collection Capacity – can be hot swapped
(150) 16x125 mm
(150) 16x150 mm
(140) 18x150 mm
(60) 25x150 mm
Bottle Racks – 480 ml
480 ml bottles available
Funnel Rack (36)
RFID Rack Identification
Identifies rack sizes
Prevents overfilling or incorrect tube selection

18. Torrent Collection Option 2
Torrent Fraction Valve
Collect up to 6 large volume fractions and a separate waste for defined protocols
Collect based on Volume with triggers from detected Threshold, Slope and/or Time Windows
Collect a given volume per container – up to 99 L

19. Torrent Collection Option 3
Manual collection – no collector necessary
Collect by hand

20. RediSep Rf and RediSep Rf Gold Columns
RFID sensors for fast setup
Run 80 gram up to 3 kg columns
Scale up from an 80 gram
Scale up from the CombiFlash Rf+
750g, 1.5 kg and 3 kg columns have large inlets and outlets to prevent flow restriction and crystallization
GOLD Speed and GOLD Resolution methods on RediSep Rf Gold silica columns
Save half the solvent

21. The Real Driver to Sell a Torrent
Post Sales Revenue
At the end of 2012 there were 70 Torrents in the field
Annually each Torrent used an average of:
750G RediSep 5
1500G RediSep 4
3000G RediSep 3
750G Gold 1
1500G Gold 2
3000G Gold 2
Over $9K in columns/instrument/year
Teledyne Isco Confidential

22. Safety Features Vapor Sensors Pressure Sensors
Air purge for easy disposal of columns
Audible alarm when user intervention is required
Removable, washable drain tray
Static-dissipative tubing throughout
Patented level sensing ensures adequate solvent for purification and prevents waste flow
Ability to network the system, watch progress, and make run adjustments from any location through either a PC or iPad

23. Key Markets Pharmaceutical Drug Discovery Agricultural Chemistry
Petrochemicals
Natural Products
Foods and Flavors
Teledyne Isco Confidential