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Comparison of two tobramycin nebuliser solutions: Pharmacokinetic, efficacy and safety profiles of T100 and TNS  Dorota Sands, Ewa Sapiejka, Grzegorz.

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Presentation on theme: "Comparison of two tobramycin nebuliser solutions: Pharmacokinetic, efficacy and safety profiles of T100 and TNS  Dorota Sands, Ewa Sapiejka, Grzegorz."— Presentation transcript:

1 Comparison of two tobramycin nebuliser solutions: Pharmacokinetic, efficacy and safety profiles of T100 and TNS  Dorota Sands, Ewa Sapiejka, Grzegorz Gąszczyk, Henryk Mazurek  Journal of Cystic Fibrosis  Volume 13, Issue 6, Pages (December 2014) DOI: /j.jcf Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 Disposition of patients and populations for analyses.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 Mean plasma (top) and sputum (bottom) tobramycin concentrations over time on Day 28 after administration of T100 (squares) or TNS (rhombi) in the overall study population (PK Analysis Set). Bars represent the 95% confidence intervals. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

4 Fig. 3 Top: Reduction of P. aeruginosa CFU calculated from beginning until end of each treatment cycle (T100: red; TNS: blank); *p<0.05, and **p<0.01. Bottom: Change of FEV1 % predicted determined at the beginning and the end of each treatment cycle (T100: red; TNS: blank); *p<0.01; and **p< Bars represent the standard deviations. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions


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