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The Biologic Basis of Migraine

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Presentation on theme: "The Biologic Basis of Migraine"— Presentation transcript:

1 The Biologic Basis of Migraine

2 Migraine Is Inherited

3 Atypical Activation Patterns in the Migraine Brain in Response to Visual, Olfactory, and Painful Stimuli

4 Migraine Multiphasic Paroxysmal Neurologic Disorder

5 Migraine Attack Begins With Activation of the Hypothalamus and Functional Coupling Between Hypothalamus and Trigeminal Nucleus

6 Aura Phase Involves a Cortical Spreading Depolarization (Depression) and Secondary Blood Flow Changes

7 Aura Results in Activation of Peripheral Trigeminal Sensory Pain Fibers and Central Trigeminovascular System

8 The Anatomy of Migraine Headache

9 Postdrome Unlike Prodrome Phase, Is Associated With a Global Reduction in Cerebral Blood Flow

10 Triptans Selective 5-HT1B/1F Receptor Agonists

11 Trigeminal Sensory Fiber Activation and CGRP

12 Understanding the Biologic and Molecular Bases Unveils Unique Therapeutic Targets

13 Abbreviations

14 Abbreviations (cont)


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