1. Sex Determination Gametogenesis Male Reproduction
Part 1: Chapter 26

2. Outline (part I) Sex determination (male versus female fetus)
sry gene
Hormonal control
Wolfiann ducts
Mullerian ducts
Gametogenesis
Timing of gamete production
Basic patterns of hypothalamic and gonadal hormone secretions
Male reproduction
Major structures
Maturation and passage of spermatozoa
Miracle of Life (film)

5. Sexual Differentiation 2nd month of development

6. Initially Bi-potential…
Gonads
Internal genitalia
External genitalia or

7. Bi potential internal genitalia
Wolffian ducts develop into:
Seminal vesicles
Vas deferens
epididymis
Fetal (male) Sertoli Cells secrete
anti-Muellerian substance
Müllerian ducts
Directed by testosterone (Leydig Cells of fetal testes)
Inhibits Müllerian ducts

8. Testosterone and MIS
Internal Genitalia

9. Binds to DNA and Gonad Differentiation
MALES SRY GENE
Testis Determination Factor
Binds to DNA and Gonad Differentiation

10. Binds to DNA and Gonad Differentiation
FEMALES NO SRY GENE!
I don’t have an SRY gene.
NO!
Testis Determination Factor NO
Binds to DNA and Gonad Differentiation

11. The timing of gametogenesis
In males
In females

13. Fertilization and the second meiotic division
Fertilization of an ovum

14. Male Reproduction and Spermatogenesis

15. Male Reproductive Tract

16. Cryptochidism: failure of testes to descend

17. epididymis
TESTIS

18. Will now look at the structure and function of this region

19. Responds to LH
Responds to FSH
64 days

21. Sertoli Cells Sertoli Cells Nourish developing sperm Secretes Inhibin
Androgen Binding Proteins

22. Cells of Leydig
Cells of Leydig
Produce testosterone

25. 12 more days!

27. Parasympathetic
(term relevant to autonomic nervous system that we will discuss when we begin the nervous system.

28. Ejaculation 200,000,000 sperm!! sympathetic nervous system
Muscular contraction associated with event termed orgasm.
200,000,000 sperm!!

29. Review: Polygenic Disorder
Klinefelter Syndrome

30. Review: Polygenic Disorder

31. Onto Female Reproduction