1. Bell Work 02/18/2015
Get out a new piece of paper to start a new round of Bell Works
Put Today’s Date & Answer the Following Questions:
What type of cell do you have the most of in your blood?
What is the function of platelets
The decreased oxygen carrying capacity of erythrocytes is called _________________________.

2. Blood Groups

3. Do Not Copy!!

4. Do Not Copy!! Population group O A B AB Rh+
European-American
African-American
Korean-American
Japanese-American
Chinese-American
Native American

5. Blood Types
ABO & Rh
Antigen (agglutinogens) – proteins on the surface of erythrocytes – determine the blood type

6. ABO Blood Groups
Determined by the presence/absence of antigens A & B which are carried on the surface of RBCs
Antigen A & Antigen B
O IS THE ABSENSE OF ANTIGENS
Antibodies are the opposite (located in the plasma)
EX: type A blood has type A antigen and antibodies for B (anti-B antibodies)
Type AB blood has type A and type B antigens and antibodies against neither
Too large to cross placenta

7. Huh???
Classification of human blood is based on inherited properties of RBCs which is determined by the presence or absence of the antigen A and B, which are carried on the surface of red cells.
Blood types:
A, B, AB, O
Blood cells with type A antigen on their surface has in its serum (fluid) ANTIBODIES that fight against B red cells.
So, if in a transfusion, type B blood is injected is into a persons blood with type A, the cells in the injected blood will be destroyed by the antibodies in the recipient’s blood.

9. Most complex blood groups An antigen
RH Blood Groups
Most complex blood groups
An antigen
You either have it (+) or you don’t (-)
Do not develop antibodies automatically; need exposure first.
1st exposure = no transfusion reaction

10. Transfusion Reactions
Antibodies bind to antigens of donor = agglutination, RBCs rupture and hemoglobin leaks out clogging kidneys leading to kidney failure

11. Hemolytic Disease of the Newborn (erythroblastosis fetalis)
Major cause of fetal loss & death among newborn babies
Blood types of mother and baby are incompatible
Rh Incompatibility & ABO incompatibility
Can be treated
If baby’s incompatible blood cells cross over to his/hermother (through placenta during pregnancy or at delivery), her immune system sees them as foreign and responds by developing antibodies to attack and break them down.

12. Hemolytic Disease of the Newborn (erythroblastosis fetalis)
Rh Incompatibility (most frequent):
Mother with Rh- negative blood becomes pregnant by an Rh- positive father, resulting in Rh- positive baby
Prevention, RhoGAM (prevent mother forming antibodies) in Rh- mothers after every birth