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Diversity of Polyubiquitin Chains

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1 Diversity of Polyubiquitin Chains
Anirban Adhikari, Zhijian J. Chen  Developmental Cell  Volume 16, Issue 4, Pages (April 2009) DOI: /j.devcel Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Ubiquitination and Proteasomal Degradation of Ubiquitinated Substrates (A) Schematic illustration of the ubiquitination cascade of a substrate and its subsequent degradation by the 26S proteasome. (B) Structure of ubiquitin (PDB code: 1UBQ) showing seven lysine residues of ubiquitin and the functional consequence of different types of lysine linkages in polyubiquitin chains. (C) Role of K11 polyubiquitination in endoplasmic reticulum-associated degradation (ERAD). Misfolded proteins in the ER are ubiquitinated by membrane-bound E2 and E3 enzymes through K11 of ubiquitin. The ubiquitinated proteins are extracted to the cytosol and then degraded by the 26S proteasome. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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