1. Submodules of the light yellow module define distinct interneuron classes with common developmental origins.
Submodules of the light yellow module define distinct interneuron classes with common developmental origins. Expression within each of these submodules is shown in the heatmap and summarized with the module eigengene (described above). The visualization of these modules was performed using VisANT to plot the 250 strongest connections within each module. Genes that are positively correlated are connected by blue lines, whereas genes that are inversely correlated are connected by red lines. (A) The first submodule contains genes co‐regulated in all telencephalic interneurons in this analysis, and Dlx1 and Arx are central genes, which is consistent with their known roles as important interneuron specifiers. (B) The second submodule contains genes regulated in cholecystokinin‐positive interneurons, which are derived from the caudal ganglionic eminence. (C) The third submodule contains genes regulated in somatostatin‐ and parvalbumin‐positive interneurons, which are both derived from the medial ganglionic eminence. Lhx6 is highly connected in this module, which is consistent with its role in the development of interneurons from the medial ganglionic eminence.
Kellen D Winden et al. Mol Syst Biol 2009;5:291
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