1. a) Schematic example of an umbrella trial.
a) Schematic example of an umbrella trial. These trials embrace centralised analysis to define the molecular portrait and molecularly selected cohorts with matched drugs [7]. These trials may fall into the “trial to conclude” category. b) Schematic illustration of the SAFIR02_Lung trial (Intergroup Trial UNICANCER UC /IFCT 1301). This is an open-label, multicentric, randomised, phase II trial [11]. NSCLC: nonsmall cell lung cancer; EGFR: epidermal growth factor receptor; ALK: anaplastic lymphoma kinase; CGH: comparative genomic hybridisation. Images courtesy of Gustave Roussy Cancer Campus Grand Paris, Villejuif, France.
Jessica Menis et al. Eur Respir Rev 2014;23:
©2014 by European Respiratory Society