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Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity  Rekha Chaudhuri,

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Presentation on theme: "Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity  Rekha Chaudhuri,"— Presentation transcript:

1 Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity  Rekha Chaudhuri, MD, Charles McSharry, PhD, Jeffrey Brady, PhD, Iona Donnelly, BSc, Christal Grierson, PhD, Stephen McGuinness, BSc, Lisa Jolly, BSc, Christopher J. Weir, PhD, C. Martina Messow, PhD, Mark Spears, PhD, Gino Miele, PhD, Karl Nocka, PhD, Dan Crowther, PhD, Joyce Thompson, BSc, Maureen Brannigan, BSc, Jane Lafferty, BSc, Michael Sproule, MBChB, William MacNee, MD, Martin Connell, BSc, John T. Murchison, FRCR, Malcolm C. Shepherd, PhD, Giora Feuerstein, MD, Douglas K. Miller, PhD, Neil C. Thomson, MD  Journal of Allergy and Clinical Immunology  Volume 129, Issue 3, Pages e8 (March 2012) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Sputum MMP-12 protein levels (A) and activity (B) in patients with different severity levels of COPD and asthma and in healthy control subjects. There were no significant differences (P > .05) among patients with mild, moderate, and severe disease in each category. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Sputum leukocyte MMP12 mRNA expression measured by using qPCR and expressed as a log10 fold change in the asthma and COPD smoking categories relative to the mean expression value of the healthy nonsmoking control group normalized for β-actin. A scatter plot including the 95% CI for the mean is shown. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Increasing sputum MMP-12 enzyme activity is associated with emphysema score measured by means of CT assessment of emphysema (%LAA−950) in patients with COPD (r = 0.442; 95% CI, ). Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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