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Granulocyte Colony-Stimulating Factor–Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host.

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Presentation on theme: "Granulocyte Colony-Stimulating Factor–Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host."— Presentation transcript:

1 Granulocyte Colony-Stimulating Factor–Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease  Sumithira Vasu, Susan Geyer, Anissa Bingman, Jeffery J. Auletta, Samantha Jaglowski, Pat Elder, Lynn O. Donnell, Hillary Bradbury, Rhonda Kitzler, Leslie Andritsos, William Blum, Rebecca Klisovic, Sam Penza, Yvonne Efebera, Craig Hofmeister, Don M. Benson, Natarajan Muthusamy, Gerard Lozanski, Steven M. Devine  Biology of Blood and Marrow Transplantation  Volume 22, Issue 4, Pages (April 2016) DOI: /j.bbmt Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Forest plot of allograft immune subsets and association with aGVHD. (A) Univariate analysis for aGVHD using aGVHD-based cut points for infused cell dose/kg. (B) Multivariate analysis for aGVHD using aGVHD-based cut points for infused cell dose/kg. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 (A) Influence of activated T cell (CD3+ HLA-DR+) allograft content on aGVHD, relapse, nonrelapse mortality, and OS. A cut point of 160 × 106 cell/kg was used. (B) Influence of HLA-DR+CD3+ cells in the allograft on cGVHD, relapse, nonrelapse mortality, and OS. NRM indicates nonrelapse mortality. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Influence of KIR-positive, activated NK cell allograft content on aGVHD, relapse, nonrelapse mortality, and OS. Cut point was 18 × 106 cells/kg. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Forest plot of allograft immune subsets and association with cGVHD. (A) Univariate analysis for cGVHD using cGVHD-based cut points for infused cell dose/kg. (B) Multivariate analysis for cGVHD using cGVHD-based cut points for infused cell dose/kg. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

6 Figure 5 Clinical factors influencing post-transplant outcomes. (A) Influence of graft source on aGVHD, nonrelapse mortality, relapse and OS. (B) Influence of recipient age (>60 years) on cGVHD, relapse, nonrelapse mortality, and OS. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions


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