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Impact of Postgrafting Immunosuppressive Regimens on Nonrelapse Mortality and Survival after Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplant.

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Presentation on theme: "Impact of Postgrafting Immunosuppressive Regimens on Nonrelapse Mortality and Survival after Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplant."— Presentation transcript:

1 Impact of Postgrafting Immunosuppressive Regimens on Nonrelapse Mortality and Survival after Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplant Using the Fludarabine and Low-Dose Total-Body Irradiation 200-cGy  Liang-Piu Koh, Chien-Shing Chen, Bee-Choo Tai, William Y.K. Hwang, Lip-Kun Tan, Hong-Yen Ng, Yeh-Ching Linn, Mickey B.C. Koh, Yeow-Tee Goh, Belinda Tan, Shan Lim, Yee-Mei Lee, Kar-Wai Tan, Te-Chih Liu, Heng-Joo Ng, Yvonne S.M. Loh, Benjamin M.F. Mow, Daryl C.L. Tan, Patrick H.C. Tan  Biology of Blood and Marrow Transplantation  Volume 13, Issue 7, Pages (July 2007) DOI: /j.bbmt Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 A, Cumulative incidence of aGVHD and cGVHD of 67 patients undergoing nonmyeloablative allogeneic transplantation. B, Grade III-IV GVHD. C, Chronic GVHD of 67 patients undergoing nonmyeloablative allogeneic transplantation stratified by postgrafting immunosuppression. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 A, NRM and B, relapse rate of 67 patients undergoing nonmyelablative allogeneic transplantation stratified by postgrafting immunosuppression. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 A, OS, current PFS (CPFS), and PFS of 67 patients undergoing nonmyeloablative allogeneic transplantation. B, OS, and C, PFS of 67 patients undergoing nonmyeloablative allogeneic transplantation stratified by postgrafting immunosuppression. D, Overall survival. E, current PFS of 67 patients stratified by disease categories and post-grafting immunosuppression. F, OS and PFS of a subgroup of 21 patients with “standard-risk” disease given MTX/MMF/CSP as postgrafting immunousppression. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

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