Presentation is loading. Please wait.

Presentation is loading. Please wait.

Murat Ulukus, M. D. , E. Cagnur Ulukus, M. D. , Ege N

Similar presentations


Presentation on theme: "Murat Ulukus, M. D. , E. Cagnur Ulukus, M. D. , Ege N"— Presentation transcript:

1 Expression of interleukin-8 and monocyte chemotactic protein 1 in women with endometriosis 
Murat Ulukus, M.D., E. Cagnur Ulukus, M.D., Ege N. Tavmergen Goker, M.D., Erol Tavmergen, M.D., Wenxin Zheng, M.D., Aydin Arici, M.D.  Fertility and Sterility  Volume 91, Issue 3, Pages (March 2009) DOI: /j.fertnstert Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Representative micrographs of immunohistochemical staining for interleukin-8 (IL-8) in the eutopic and ectopic endometrium of women with and without endometriosis. In all normal and endometriosis samples, cytoplasmic IL-8 immunoreactivity was observed in both epithelial and stromal cells. Epithelial staining was more intense than stromal staining in all eutopic and ectopic endometrial samples. (A, C) Proliferative phase; (B, D) secretory phase. Epithelial staining was higher in the secretory phase than in the proliferative phase in normal endometrium samples (A, B). No cyclic variation was observed during the menstrual cycle in eutopic endometrium of women with endometriosis (C, D). (E) Diffuse and strong IL-8 immunoreactivity was observed in ectopic endometrial samples. Scale bars represent 200 μm (A–C); and 100 μm (D, E). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Representative micrographs of immunohistochemical staining for monocyte chemotactic protein 1 (MCP-1) in the eutopic and ectopic endometrium of women with and without endometriosis. (A, C) Proliferative phase; (B, D) secretory phase. Epithelial MCP-1 expression was similar in both phases in normal endometrial samples (A, B). Similarly, no cyclic variation was observed during the menstrual cycle in eutopic endometrium of women with endometriosis. Granular epithelial staining was observed in some secretory phase samples (C, D). (E) Diffuse and strong MCP-1 immunoreactivity was observed in ectopic endometrial samples. Scale bars represent 100 μm (A, D, E) and 200 μm (B, C). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 The distribution of interleukin-8 (IL-8) immunostaining intensity (HSCORE) in epithelial cells of normal endometrium (N Em) and eutopic endometrium (Eut Em) of women with endometriosis (according to the menstrual cycle phase) and ectopic endometrial (Ect Em) samples. Data represent the mean HSCORE of samples, and error bars represent the SEM. In normal endometrium, secretory phase samples express higher epithelial IL-8 compared with proliferative phase samples (P1=.01). However, proliferative phase eutopic endometrial samples of women with endometriosis express significantly higher epithelial IL-8 compared with normal samples (P2=.04). A higher intensity in eutopic (proliferative and secretory) and ectopic endometrium of women with endometriosis was observed compared with normal endometrium (proliferative and secretory; P3=.02). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

5 Figure 4 The distribution of monocyte chemotactic protein 1 (MCP-1) immunostaining intensity (HSCORE) in epithelial cells of normal endometrium and eutopic endometrium of women with endometriosis (according to the menstrual cycle phase) and ectopic endometrial samples. Data represent the mean HSCORE of samples, and error bars represent the SEM. In the proliferative phase, eutopic endometrial samples of women with endometriosis express significantly higher epithelial MCP-1 compared with normal samples (P1=.003). A higher intensity in eutopic (proliferative and secretory) and ectopic endometrium of women with endometriosis was observed compared with normal endometrium (proliferative and secretory; P2=.005). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions


Download ppt "Murat Ulukus, M. D. , E. Cagnur Ulukus, M. D. , Ege N"

Similar presentations


Ads by Google