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The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

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Presentation on theme: "The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones"— Presentation transcript:

1 The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
Thomas R. Cech, Joan A. Steitz  Cell  Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Noncoding RNAs Function in Diverse Contexts
Noncoding RNAs function in all domains of life, regulating gene expression from transcription to splicing to translation and contributing to genome organization and stability. Self-splicing RNAs, ribosomes, and riboswitches function in both eukaryotes and bacteria. Archaea (not shown) also utilize ncRNA systems including ribosomes, riboswitches, snoRNPs, and CRISPR. Orange strands, ncRNA performing the action indicated; red strands, the RNA acted upon by the ncRNA. Blue strands, DNA. Triangle, small-molecule metabolite bound by a riboswitch. Ovals indicate protein components of an RNP, such as the spliceosome (white oval), ribosome (two purple subunits), or other RNPs (yellow ovals). Because of the importance of RNA structure in these ncRNAs, some structures are shown but they are not meant to be realistic. Cell  , 77-94DOI: ( /j.cell ) Copyright © 2014 Elsevier Inc. Terms and Conditions


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