1. Lung Cancer Resets the Liver’s Metabolic Clock
Rob A. Cairns, Tak W. Mak 
Cell Metabolism 
Volume 23, Issue 5, Pages (May 2016)
DOI: /j.cmet
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Mutant Kras/p53 Null Lung Adenocarcinoma Alters Circadian Rhythms in the Liver
The development of lung adenocarcinoma driven by conditional activation of the KrasG12D mutation and loss of the p53 tumor suppressor leads to altered circadian patterns of transcription of a subset of genes in the liver. This phenomenon is observed in the absence of malignant cells in the liver itself and without alterations to the core circadian clock machinery. These transcriptional changes lead to altered patterns of liver metabolism across the circadian cycle, including insulin signaling, glucose production, and lipid metabolism. An inflammatory response via the STAT3 signaling axis is also observed locally in the liver but not in other tissues. It is unclear what mechanism signals from the lung to the liver in order to cause these perturbations, but tumor-derived metabolites, cytokines, or the immune system may all play a role.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2016 Elsevier Inc. Terms and Conditions