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HLA-F: A New Kid Licensed for Peptide Presentation

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1 HLA-F: A New Kid Licensed for Peptide Presentation
Malcolm J.W. Sim, Peter D. Sun  Immunity  Volume 46, Issue 6, Pages (June 2017) DOI: /j.immuni Copyright © Terms and Conditions

2 Figure 1 HLA-F Interacts with Immune Receptors in Both Peptide-Bound and Open Conformations Left: A summary of interactions currently known to involve either the open conformer or β2M and peptide-complexed HLA-F (shown in blue ovals) and various KIR (orange ovals), LIR1 (green ovals). Potential new HLA-F binding KIR and TCR are shown in red and pink, respectively. Right: Enlarged view of the center highlighted region showing both the crystal structure of LIR1 (shown in green) with peptide-bound HLA-F (in blue ribbons) by Dulberger et al. (2017) (PDB: 5KNM) and a potential interaction with KIR involving peptide, modeled from the structure of HLA-C∗03:04 & KIR2DL2 complex by Boyington et al. (2000) (PDB: IEFX). Immunity  , DOI: ( /j.immuni ) Copyright © Terms and Conditions


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