1. Pathogen Recognition: TLRs Throw Us a Curve
Peter Kirk, J. Fernando Bazan 
Immunity 
Volume 23, Issue 4, Pages (October 2005)
DOI: /j.immuni
Copyright © 2005 Elsevier Inc. Terms and Conditions

2. Figure 1 The Proposed Dimer Architecture of the TLR3 Ectodomain
The crystallographic complex of TLR3 chains (PDB ID code 2A0Z; Bell et al., 2005) shows the protein surface colored by electrostatic potential (red, positive; blue, negative charge) with N-glycan chains in green. The proposed ligand binding groove is depicted by a dotted orange ball; gray arrows mark possible rearrangements that would bring the C termini closer together, further open the binding groove, and drive intracellular signaling by the receptor TIR domains. Composed with Pymol (
Immunity  , DOI: ( /j.immuni )
Copyright © 2005 Elsevier Inc. Terms and Conditions