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Inhibition of neointimal hyperplasia in a sheep model of dialysis access failure with the bioabsorbable Vascular Wrap⁎ paclitaxel-eluting mesh  Ted R.

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Presentation on theme: "Inhibition of neointimal hyperplasia in a sheep model of dialysis access failure with the bioabsorbable Vascular Wrap⁎ paclitaxel-eluting mesh  Ted R."— Presentation transcript:

1 Inhibition of neointimal hyperplasia in a sheep model of dialysis access failure with the bioabsorbable Vascular Wrap⁎ paclitaxel-eluting mesh  Ted R. Kohler, MD, MSc, Philip M. Toleikis, PhD, David M. Gravett, PhD, Rui L. Avelar, MD  Journal of Vascular Surgery  Volume 45, Issue 5, Pages e3 (May 2007) DOI: /j.jvs Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Schematic diagram of right external jugular vein and expanded polytetrafluoroethylene (ePTFE) graft anastomosis with applied mesh and histologic sections. Journal of Vascular Surgery  , e3DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Example of a section through the toe of the graft (section 4) at low power showing where capillary density was measured in the neointima (bar represents 4 mm). The inset is a high power (bar represents 400 μm) from this region demonstrating multiple capillaries (arrow). Journal of Vascular Surgery  , e3DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 In vitro drug elution curves (presented with mean ± standard deviation) for paclitaxel from the polyglycolic-polylactid acid mesh at the three concentrations used in this experiment, 0.3 (diamonds), 0.7 (squares), and 1.2 (triangles) μg/mm2. Journal of Vascular Surgery  , e3DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Dose effect of paclitaxel on neointimal area (presented with mean ± SEM). *P < .05 vs 0 mg mesh group; there was no neointima formation with the two highest-dose mesh groups in graft section 6. All P values reported are based on pair-wise comparisons made using the Wilcoxon rank sum test; the ranges of P values based on the Fligner-Policello test statistic are reported in Appendices B and C, online only. Journal of Vascular Surgery  , e3DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

6 Fig 5 Left, Photomicrograph of a representative section 5 from the zero-dose mesh control and (right) 1.2 μg/mm2 paclitaxel mesh group (bar represents 4 mm). M, Mesh, G, ePTFE graft; N, neointima; T, thrombus; V, vein; and L, lumen. Journal of Vascular Surgery  , e3DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

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