1. The role of protein kinase C activation in diabetic nephropathy
H. Noh, G.L. King 
Kidney International 
Volume 72, Pages S49-S53 (August 2007)
DOI: /sj.ki
Copyright © 2007 International Society of Nephrology Terms and Conditions

2. Figure 1
This Schema shows our hypothesis of diabetic nephropathy. Hyperglycemia activates PKC and increase connective tissue growth factor and TGF-β, which lead to mesangium expansion and nephromegaly. Mesangium expansion due to matrix deposition results in glomerular sclerosis and diabetic nephropathy.
Kidney International  , S49-S53DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions