1. Sequence similarity cluster of SPOUT methyltransferases.
Sequence similarity cluster of SPOUT methyltransferases. All of the known and putative SPOUT methyltransferases were analyzed by CLANS with reference proteins to infer substrate specificity. All human SPOUT methyltransferases are in black and identified with arrows. Reference proteins in the NEP1 subfamily are in red, and those in the TrmH subfamily are in yellow. Yeast proteins YGR283C and YMR310C are in dark and light blue, respectively, and guanine-N1-9-methyltransferase reference proteins are in pink. BLAST correlations are shown with gray lines; lighter shades of gray represent BLAST correlations closer to an E-value of 1, whereas darker shades of gray represent BLAST correlations that are closer to an E-value of 0.
Tanya C. Petrossian, and Steven G. Clarke Mol Cell Proteomics 2011;10:M
© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.