1. Biochemical function of PRPP
Biochemical function of PRPP. The β,γ-diphosphoryl group of ATP is transferred to ribose 5-phosphate with the generation of PRPP in a reaction catalyzed by PRPP synthase, which is encoded by a prs gene.
Biochemical function of PRPP. The β,γ-diphosphoryl group of ATP is transferred to ribose 5-phosphate with the generation of PRPP in a reaction catalyzed by PRPP synthase, which is encoded by a prs gene. PRPP is a substrate in a number of substitution reactions, most of which involve a nitrogen-containing compound. The reaction occurs at C-1 of the ribosyl moiety and proceeds with inversion of the configuration of this carbon and with PPi as a leaving group.
Bjarne Hove-Jensen et al. Microbiol. Mol. Biol. Rev. 2017; doi: /MMBR