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Osteoarthritis and Cartilage

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1 Osteoarthritis and Cartilage
DKK1 AND FRZB are necessary for chondrocyte (RE)differentiation and prevention of cell hypertrophy in 3D cultures of human chondrocytes and human mesenchymal stem cells  L. Zhong, X. Huang, E. Rodrigues, J. Leijten, T. Verrips, M. El Khattabi, M. Karperien, J. Post  Osteoarthritis and Cartilage  Volume 24, (April 2016) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1 Blocking of DKK1 and FRZB inhibits chondrocyte re-differentiation. Histological analysis of mid-sagittal sections of the chondrocyte pellets using Alcian blue staining for GAGs (A) and immunohistochemistry staining for collagen type II (B). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2. DKK1 and FRZB are necessary for multiple steps during chondrogenesis to ensure chondrogenesis and to prevent cell hypertrophy in terminal differentiation. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions


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