1. Volume 75, Issue 4, Pages 366-372 (February 2009)
Accelerated development of collapsing glomerulopathy in mice congenic for the HIVAN1 locus 
Ka T. Chan, Natalia Papeta, Jeremiah Martino, Zongyu Zheng, Rachelle Z. Frankel, Paul E. Klotman, Vivette D. D'Agati, Richard P. Lifton, Ali G. Gharavi 
Kidney International 
Volume 75, Issue 4, Pages (February 2009)
DOI: /ki
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2. Figure 1
Histology of TgFVB-HIVAN1CAST mice (PAS stain). Congenic mice display advanced global glomerulosclerosis (a–c) or collapsing glomerulosclerosis with podocyte hyperplasia (d–f). (a and d) Low power view (× 200) demonstrates diffuse and global glomerulosclerosis, extensive microcystic tubular dilatation and severe tubulointerstitial injury. (b and c) High power views (× 400) of glomeruli showing global sclerosis and podocyte depletion. Higher power views (× 600) of glomeruli showing collapsing sclerosis (e) with podocyte hyperplasia and cytoplasmic vacuolization (f).
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3. Figure 2
Phenotypic comparison of TgFVB and TgFVB-HIVAN1CAST mice. Comparison of proteinuria (a) and glomerulosclerosis scores (b) in HIV-1 transgenic mice carrying different alleles at the HIVAN1 locus on chromosome 3A1–A3. Values for a cohort of nontransgenic (nonTg) mice of all three genotypes are shown for comparisons. (c) Comparison of HIV-1 Env expression in mice carrying different alleles at the HIVAN1 locus. #P<0.005, *P<0.05 vs Tg FVB/FVB genotype.
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4. Figure 3
Fine mapping of the HIVAN1 locus. (a) LOD plots for renal histology scores in the F2 intercross between TgFVB and TgFVB-HIVAN1CAST strains. Map distance is presented in cM. The positions of informative markers are shown above each plot. The dashed horizontal lines indicate the empiric threshold for 95th and 99th percentile significance level based on 10,000 permutations (1.9 and 3.2, respectively). The 95th confidence interval for the location of the HIVAN1 gene is shown above the LOD plot. (b) Phenotypic effects of HIVAN1 genotype in F2 cross is consistent with an additive model (mean±s.e.m.).
Kidney International  , DOI: ( /ki )
Copyright © 2009 International Society of Nephrology Terms and Conditions