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The AB-180 circulatory support system: summary of development and plans for phase I clinical trial  Edward B Savage, MD, Richard E Clark, MD, Wayne P.

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Presentation on theme: "The AB-180 circulatory support system: summary of development and plans for phase I clinical trial  Edward B Savage, MD, Richard E Clark, MD, Wayne P."— Presentation transcript:

1 The AB-180 circulatory support system: summary of development and plans for phase I clinical trial 
Edward B Savage, MD, Richard E Clark, MD, Wayne P Griffin, MS, Scott A Davis, Suzanne Hughson, MS, Christopher J Conway, MS, George J Magovern, MD  The Annals of Thoracic Surgery  Volume 68, Issue 2, Pages (August 1999) DOI: /S (99)

2 Fig 1 Diagram of implanted AB-180 CSS pump.
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

3 Fig 2 The AB-180 circulatory support system (AB-180 CSS).
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

4 Fig 3 AB-180 CSS pump assembly.
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

5 Fig 4 Four sets of pressure-volume loops for a 37-kg sheep taken before left heart bypass and at approximately 25%, 50%, and 75% bypass of right heart cardiac flows. The cardiac output at zero pump flow was 4.7 L/min and the pump flows were 1.4, 2.5, and 3.5 L/min for the 25%, 50%, and 75% bypass recordings, respectively. Note that virtually all of the work reduction is achieved through decreases in end-diastolic volume. LV = left ventricular. The Annals of Thoracic Surgery  , DOI: ( /S (99) )

6 Fig 5 Left ventricular stroke work indexed and aggregated for both ascending and descending runs plotted against percent bypass. Data were pooled by deciles of percent bypass. Data are presented as the mean ± 1 standard error of the mean. Note the near-linear relation between the variables. The Annals of Thoracic Surgery  , DOI: ( /S (99) )

7 Fig 6 Left ventricular oxygen consumption (LVVO2) versus percent bypass for all runs. See legend for Figure 5. Data points were relatively smooth, except at 50% and 80% bypass levels. The Annals of Thoracic Surgery  , DOI: ( /S (99) )


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