1. Effects of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation: A Meta-analysis 
Elizabeth J. Videlock, Vivian Cheng, Filippo Cremonini 
Clinical Gastroenterology and Hepatology 
Volume 11, Issue 9, Pages e3 (September 2013)
DOI: /j.cgh
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2. Figure 1
Forest plot showing random-effects RR estimates with the corresponding 95% CI for being a responder on linaclotide vs placebo in IBS-C. (A) FDA responder; (B) abdominal pain responder; (C) CSBM responder; (D) adequate relief responder.
Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh )
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3. Figure 2
Forest plot showing random-effects RR estimates with the corresponding 95% CI for being a responder on linaclotide vs placebo in CC. (A) CSBM responder; (B) abdominal discomfort responder; (C) adequate relief responder.
Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh )
Copyright © 2013 AGA Institute Terms and Conditions

4. Figure 3
Forest plot showing RR of developing diarrhea on low and higher dose linaclotide compared with placebo.
Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh )
Copyright © 2013 AGA Institute Terms and Conditions

5. Supplementary Figure 1 Meta-analysis flow.
Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh )
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6. Supplementary Figure 2
Forest plot showing comparative and pooled effect of the 290- to 300-μg dose of linaclotide in IBS-C.
Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh )
Copyright © 2013 AGA Institute Terms and Conditions