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Diet and Lifestyle Influences on Breast Cancer
Keith D. Bishop Clinical Nutritionist B.Sc. Pharmacy
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The following research summary and seminar is for information and education use only.
The information and commentary provided are not intended to replace your doctors care. You should consult with your health care provider before making changes in your prescription, cancer treatment, diet, lifestyle and supplement program. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet and Lifestyle Seminar
Diet and Lifestyle Influences on Prostate Cancer Breast Cancer Diet and Lifestyle Seminar I’m providing a summary of recent research on the effects diet and lifestyle has on breast cancer This research information will enlighten and empower you in your quest for a healthier life. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy Natural Care Solution - Health Nut Rx
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Breast Cancer Diet and Lifestyle Seminar
You will have the basic tools to maximize your body’s ability to prevent and fight breast cancer, all other cancers and most other causes of early death. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Oklahoma
The breast cancer death rate in Oklahoma exceeds that of the United States. J Okla State Med Assoc Jan;101(1):15-9 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Risks Breast cancer does not have a single cause.
Breast cancer does have some risk factors including age, race and family history or genetics. Breast cancer grows up to 8 years before being diagnosed. Intelligent Patient Guide to Breast Cancer by Ivo Olivotto, MD, Karen Gelmon, MD, Urve Kuusk, MD, Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer: Risks Research shows many modifiable factors in our environment, diet and lifestyle influence the prevention, development, growth and death of breast cancer cells. Our body has natural mechanisms that can assist or hinder the ability to fight cancers. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Risks Eating a nutritious diet, being physically active, and keeping body fat under control may prevent: 38% of Breast Cancers 45% of Colorectal Cancers 70% of Endometrial Cancers The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR). Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet - Calories
Energy intake >2,057 calories per day was significantly and positively related to breast cancer risk. Breast J Sep-Oct;15 Suppl 1:S63-71 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet - Coffee
Women who drank more than eight cups of coffee per day had an increased risk of breast cancer. Breast J Sep-Oct;15 Suppl 1:S63-71 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Tea (new slide)
Increased green tea consumption (more than three cups a day) decreased breast cancer recurrence by 73% Increased green tea consumption decreased breast cancer risk by 81% Breast Cancer Res Treat May 13. In women <50 years of age, consuming three or more cups per day had a 37% reduced breast cancer risk when compared with women reporting no tea consumption. Cancer Epidemiol Biomarkers Prev Jan;18(1):341-5. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet - Alcohol
Subjects who drank >9 gm of alcohol (ethanol) per day had an increased risk of breast cancer 1 jigger (1.5 oz) = 14 gm alcohol A positive and significant association was noted between the consumption of beer, wine and spirits, and breast cancer risk. Breast J Sep-Oct;15 Suppl 1:S63-71 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet - Alcohol
Alcohol was significantly positively associated with total breast cancer: Even a moderate amount of alcohol (>10 gm/day) significantly increased breast cancer risk Moderate consumption of alcohol was associated with hormone receptor-positive tumors. Am J Epidemiol Aug 1;170(3):308-17 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet – Western
Western Diet (essentially meat products, French fries, appetizers, rice/pasta, potatoes, pulses, pizza/pies, canned fish, eggs, alcoholic beverages, cakes, mayonnaise, and butter/cream) increased breast cancer risk by 20% Am J Epidemiol Oct 14. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet – Mediterranean
Mediterranean Diet (essentially vegetables, fruits, seafood, olive oil, and sunflower oil) decreased breast cancer risk by 15%. Am J Epidemiol Oct 14. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet – Black Women’s Study
Western (refined grains, processed meat, and sweets) Prudent (whole grains, vegetables, fruit, and fish) Compared to Western diet the Prudent dietary pattern decreased cancer risk by 30% in premenopausal women Page 1 of 2 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet – Black Women’s Study
Prudent dietary pattern was associated with a 36% lower risk of breast cancer in women with a BMI <25 Prudent dietary pattern reduced estrogen receptor-negative (ER-) breast cancer risk by 48%. Am J Clin Nutr Sep;90(3):621-8. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet – Fruits and Vegetables
Consumption of individual vegetable and fruit groups such as dark green leafy vegetables, cruciferous vegetables, carrots and tomatoes, banana, watermelon/papaya/cantaloupe were all inversely and significantly related with breast cancer risk. Int J Cancer Jul 1;125(1):181-8. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet – Fruits and Vegetables
Higher intake of fruits and vegetables combined was associated with a significant decreased in the risk of breast cancer. Asian Pac J Cancer Prev Jul-Sep;10(3):419-28 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Diet – Fruits and Vegetables
A diet high in vegetables, fruit, and fiber and low in fat decreased additional risk of secondary breast cancer events in women without hot flashes (diet of 5 servings of vegetables and fruit daily) Am J Clin Nutr May;89(5):1565S-1571S. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Meat High intake of red meat, total meat and processed meat increased the risk of breast cancer Asian Pac J Cancer Prev Jul-Sep;10(3): A meta-analysis shows an association between breast cancer risk and red meat consumption in premenopausal women Breast Cancer Res Treat Sep;117(1):1-8. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Meat Breast cancer risk increased by 56% for each additional 100 gm/day of meat consumption 6 oz steak = 170 gm Nutr Cancer. 2008;60(2):177-87 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Red Meat Positively associated with breast cancer:
Heterocyclic amines (well cooked, grilled or burnt meat) Iron Br J Cancer Jul 7;101(1): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Red Meat – Fried Meat
Red meat did not increase breast cancer risk Fried meat intake increased the risk of ER+/PR- breast cancer Eur J Cancer May 20. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega-3 High consumption of omega-3 from fatty fish is associated with a reduced risk for breast cancer 19% lower risk in premenopausal women 27% lower risk in postmenopausal women Page 1 of 3 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega-3 Postmenopausal
Consuming 101 mg of EPA daily decreased breast cancer risk by 38% Consuming 213 mg of DHA daily decreased breast cancer risk by 32% Page 2 of 3 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega-3 Premenopausal
Highest amount of omega-3 decreased breast cancer risk by 46% Page 3 of 3 BMC Cancer Jun 30;9:216. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega 6 Fatty Acids
Cause inflammation and pain (via COX-2) Linoleic acid Corn oil Safflower oil Sunflower oil Arachidonic acid Animal Fat Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega 6 Fatty Acids
A significant increased breast cancer risk was observed among those with high intakes of omega-6 PUFAs from meat Int J Cancer Oct 1;123(7): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega 6 Fatty Acids
High consumption of processed meat, fish, butter and other animal fats, and margarine increased to risk of breast cancer by 2 fold Br J Nutr Nov;100(5):942-6 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega 3 and Omega 6 – COX-2
Omega-6 fatty acids and their derivatives promote the production of proinflammatory eicosanoids (COX-2), whereas omega-3 fatty acids suppress this action. Drug News Perspect Nov;21(9):504-10 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega 3 and Omega 6 – COX-2
Apricoxib (CS-706), a small-molecule, orally active, selective COX-2 inhibitor, is under development by Tragara Pharmaceuticals Inc as an analgesic and anti-inflammatory agent, and also for its anticancer potential. IDrugs Nov;12(11):711-22 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer: Flaxseed
25 gm of Flaxseed in a daily muffin Reduced Ki-67 index by 34.2% HER2 expression by 71% Increased apoptosis by 30.7% Compared to placebo group Clin Cancer Res May 15;11(10): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega-9 Fatty Acids
Oleic acid in olive oil (monounsaturated fatty acid) decreases the risk of breast cancer. World J Surg Oncol Jul 18;3:45 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Omega-9 Fatty Acids
Olive oil Avocado Peanuts Almonds Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Trans Fatty Acids
A high serum level of trans-fatty acids, presumably reflecting a high intake of industrially processed foods, is probably one factor contributing to increased risk of invasive breast cancer in women. Am J Epidemiol Jun 1;167(11): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Oxidative Damage
In all stages, MDA (malondialdehyde) levels in breast cancer patients were significantly higher than those in healthy subjects J Cancer Res Clin Oncol Aug;135(8): Fruits and vegetables provide antioxidants and lower MDA. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer MDA Low plasma vitamin A increased risk of breast cancer by approximately two fold Low plasma vitamin E increased the risk by two to three fold A high level of MDA was associated with breast cancer. Asian Pac J Cancer Prev Apr-Jun;9(2):343-49 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Copper Consistently, high levels of copper have been found in many types of human cancers, including prostate, breast, colon, and lung. Recent studies suggest that copper (removal) could be used as a novel selective target for cancer therapies. Cancer Res Feb 15;67(4): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Copper The copper levels in serum of healthy volunteers were lower than in cancer patients Biometals Apr;22(2):377-84 Copper is a co-factor essential for tumor angiogenesis (growth of new blood vessels) processes and high levels of copper have been found in many types of human cancers, including prostate, breast and brain. Front Biosci Sep 1;10:2932-9 Heavy Metal Test at Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Glucose Metabolic syndrome is significantly more prevalent in triple-negative (ER-, PR-, HER2-) breast cancer patients. Breast Cancer Res Treat Oct 23 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Glucose Hyperinsulinemia most likely favors cancer in diabetic patients as insulin is a growth factor with preeminent metabolic but also mitogenic effects and its action in malignant cells is favored by mechanisms acting both at the receptor and post-receptor level. Endocr Relat Cancer Jul 20. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Glucose Higher insulin-like growth factor 1 (IGF-1) levels are associated with premenopausal breast cancer risk Endocr Relat Cancer Sep 28. High insulin levels increased the risk of postmenopausal breast cancer by 46% J Natl Cancer Inst Jan 7;101(1):48-60 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Cholesterol & Glucose
Dietary Energy Restriction (DER): Reduced expressions of growth genes in the lipid metabolism and glycolytic (glucose) pathways in breast tissue Lowered serum biomarkers of breast cancer risk (insulin, leptin, total and low-density lipoprotein cholesterol, and triglycerides Cancer Prev Res (Phila Pa) Aug;2(8): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Soy A diet rich in isoflavones from soy products reduces the risk of postmenopausal breast cancer in Japanese American and White women Cancer Prev Res (Phila Pa) Oct;2(10): Genistein could be useful as a chemotherapeutic agent in premenopausal women with breast cancer of the ERalpha-negative and ERbeta-positive type Decreased estradiol stimulated cancer growth. Pharmacology. 2009;84(2):68-73. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Soy A recent nested case-control study and meta-analysis of numerous epidemiological studies show an inverse correlation between genistein intake and breast cancer risk Clinical studies in osteopenic and osteoporotic, postmenopausal women support the breast and uterine safety of purified naturally derived genistein administered for up to 3 years. Nutr Rev Jul;67(7): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Dairy Skim milk, but not other dairy foods, was associated with increased risk of advanced prostate cancer. In contrast, calcium from nondairy foods was associated with lower risk of non-advanced prostate cancer. Am J Epidemiol Dec 1;166(11): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Sunshine and Vitamin D
Sun exposure rate seemed to be positively correlated with a lower risk of overall morality due to organ cancer The health benefits of sunlight appear to outweigh the risk of skin cancer The vitamin D hormone system is necessary for cell proliferation and differentiation. Anticancer Res Jul-Aug;26(4A): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Vitamin D
In the meta-analysis of 11 research studies, there was a significant inverse relationship between vitamin D intake and breast cancer risk The highest vitamin D intake reduced breast cancer risk by 91% The highest 25 Hydroxyvitamin D3 level reduced breast cancer by 45% Breast Cancer Res Treat Oct 23. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Vitamin D
Women with breast cancer had lower plasma 25OHD levels than controls. Highest levels of 25OD levels reduces breast cancer risk by 52% Cancer Epidemiol Biomarkers Prev Oct;18(10): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Vitamin D
Vitamin D3 Blood Test 25 Hydroxyvitamin D3 Normal level 32 – 100 ng/ml Optimal level 50 – 70 ng/ml Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Exercise
Two large studies have reported that exercise decreased breast cancer mortality Estrogen pathway and the insulin pathway are two potential mechanisms Breast Cancer Res Sep 1;11(5):106. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Exercise
>7 hours/week of moderate-to-vigorous activity during the past 10 years was associated with 16% reduced risk of postmenopausal breast compared with inactivity. BMC Cancer Oct 1;9(1):349. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Bra In premenopausal women, sleeping without bra decreased the risk of breast cancer Sleeping without a bra did not decrease breast cancer in postmenopausal women. Nan Fang Yi Ke Da Xue Xue Bao Jul;29(7):1451-3 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Bra Premenopausal women who do not wear bras had half the risk of breast cancer compared with bra users Possibly because they are thinner and likely to have smaller breasts. Eur J Cancer. 1991;27(2):131-5 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Antiperspirants / Deodorants
Antiperspirants had no association with the risk of breast cancer. East Mediterr Health J May-Jul;12(3-4):478-82 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Antiperspirants / Deodorants
Frequency and earlier onset of antiperspirant/deodorant usage with underarm shaving were associated with an earlier age of breast cancer diagnosis. Eur J Cancer Prev Dec;12(6): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Antiperspirants / Deodorants
Breast cancer did not increase with antiperspirant, deodorant, product use among subjects who shaved with a blade razor, or application of antiperspirant or deodorant products within 1 hour of shaving. J Natl Cancer Inst Oct 16;94(20): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Sleep Nighttime shift work increases risk
Blindness lowers risk Long sleep duration lowers risk Community nighttime light level increases risk Mutat Res Sep-Oct;679(1-2):6-8. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Sleep Blind women with No Perception of Light appear to have a lower risk of breast cancer, compared to blind women with Light Perception. Cancer Causes Control Aug 1 Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Sleep Women shift workers report poor sleep quality and experience reproductive disturbances, an increased risk of breast cancer, and a greater risk of metabolic and cardiovascular disorders. J Womens Health (Larchmt) Jul 6. Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Sleep Sleep disturbances can lead to immune suppression and a shift to the predominance in cancer-stimulatory cytokines. Sleep Med Rev Aug;13(4): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Stress Social stress is not associated with breast cancer. Breast Cancer Res Treat Jul 2. It cannot be confidently concluded that life events, personality features or depression play a role in the onset of cancer. Rev Epidemiol Sante Publique Apr;57(2): Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Breast Cancer Free Seminar on-line at
Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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Natural Care Solution – Health Nut Rx
Collonade Center 9612 N. May Avenue, OKC, OK Copyright 2009 Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy
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