1. Plasma concentration–time profile, relative bioavailability and pharmacokinetic (PK) parameters of 4 mg TAK-228 in the single-agent QD PK run-in period, according to manufacturing process and dosing conditions. *Geometric mean; †Median; ‡Arithmetic mean. –, not available/not applicable; AUC, area under the plasma concentration–time curve; CL/F, apparent oral clearance; Cmax, maximum plasma concentration; CV, coefficient of variation; t½, plasma half-life; TAK-228+P, TAK-228 once daily 3 days/week+paclitaxel 80 mg/m2 on days 1, 8 and 15; Tmax, time of maximum plasma concentration; QW, once weekly; Vz/F, apparent terminal phase volume of distribution.
Plasma concentration–time profile, relative bioavailability and pharmacokinetic (PK) parameters of 4 mg TAK-228 in the single-agent QD PK run-in period, according to manufacturing process and dosing conditions. *Geometric mean; †Median; ‡Arithmetic mean. –, not available/not applicable; AUC, area under the plasma concentration–time curve; CL/F, apparent oral clearance; Cmax, maximum plasma concentration; CV, coefficient of variation; t½, plasma half-life; TAK-228+P, TAK-228 once daily 3 days/week+paclitaxel 80 mg/m2 on days 1, 8 and 15; Tmax, time of maximum plasma concentration; QW, once weekly; Vz/F, apparent terminal phase volume of distribution.
Kathleen N Moore et al. ESMO Open 2018;3:e000291
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