1. Date: Dec 9, 2014 Page:Table of Contents p. 1. W. O. D: Last 5 pages
Date: Dec 9, 2014 Page:Table of Contents p W.O.D: Last 5 pages Warm-ups:Front Cover W.O.D: Aneuploidy: is an abnormal number of chromosomes. Question: If your child is diagnosed with aneuploidy in the womb, what should you expect?

2. Table of Contents p. 1 Science News “Born to Heal” p.2
Chromosome Notes p. 3
Double Helix p. 4
Karyotype Notes p. 5

3. Karyotyping : P. 5 SNB (Number 1- 11)
Look at the green karyotype in front of you.
What can you observe about the pattern of the chromosomes?
What gender do you have on your karyotype?
Compare with your neighbor. How is theirs different?

4. Autosomes vs Sex Chromosomes
Which chromosomes on the karyotype are autosomes?
Chromosome pairs 1-22 are autosomes. One chromosome from each parent makes up a pair of autosomes.
Which chromosomes are sex chromosomes?
Sex chromosomes are pair 23 (X and Y). The first X is from the mother. The second chromosome, which determines gender, is from the father.

5. Autosomes vs Sex Chromosomes
5. Which chromosomes on the karyotype are autosomes? List their numbers in your SNB.
6. Which chromosomes are sex chromosomes? Write their numbers in your SNB.

6. Aneuploidy in Karyotyping
Look at the blue karyotype.
7. What differences do you see in this karyotype compared to the green one?
8. Can you identify what your blue karyotype shows?
9. Compare with your neighbor. Is theirs different?

7. 10. How does aneuploidy happen?
Nondisjuntion

8. 11. Which karyotype do you have?
Trisomy 18 –Edward’s Syndrome
Trisomy 21
Down syndrome
XYY “Syndrome”
XXY Klinefelter’s Syndrome
Trisomy 13 – Patau syndrome
X - Turner Syndrome

9. Read about your child’s chromosomal disorder
Read about your child’s chromosomal disorder. Then prepare to present a summary of the causes and characteristics of this form of aneuploidy.

10. Reflection: Which chromosomal aneuploidy did your child have?
Trisomy 18 –Edward’s Syndrome
Trisomy 21
Down syndrome
XYY “Syndrome”
XXY Klinefelter’s Syndrome
Trisomy 13 – Patau syndrome
X - Turner Syndrome