2 Disorders Caused by Nondisjunction of Autosomal Chromosomes: There only 3 autosomal trisomies that result in a baby that can survive for a time after birth; the others are too devastating and the baby usually dies in utero.There are no instances of autosomal monosomies surviving after birth.
3 Down Syndrome (trisomy 21): 47, XX, +21 or 47, XY, +21 The result of an extra copy of chromosome 21.Down syndrome alters the child's physical appearance either moderately or severely.characteristic facial features, short stature; heart defects, shorter lifespan
4 often sexually underdeveloped and sterile, usually some degree of mental retardation. Down Syndrome is correlated with age of mother but can also be the result of nondisjunction of the father's chromosome 21.
5 B. Patau syndrome (trisomy 13): 47, XY, +13 or 47,XX, +13 serious eye, brain, circulatory defects as well as cleft palate children rarely live more than a few months
6 C. Edward's syndrome (trisomy 18): 47, XX, +18 or 47, XY, +18 almost every organ system affectedchildren with full Trisomy 18 generally do not live more than a few months.
7 Disorders Caused by Nondisjunction of Sex Chromosomes Can be fatal, but many people have these karyotypes and are just fine!
8 D. Monosomy X (Turner's syndrome): 45, XO the only viable monosomy in humansgenetically female, however, they do not mature sexually during puberty and are sterile.Short stature and normal intelligence. (98% of these fetuses die before birth)
9 E. Klinefelter’s Syndrome: 47, XXY genetically maleindividuals have male sex organs, but usually small testes and are sterilemay have breast enlargement and other feminine body characteristics.Normal intelligence
10 F. Trisomic Females: 47, XXX healthy and fertile - usuallycannot be distinguished fromnormal female except by karyotypeXYY Males: 47, XYYIndividuals are somewhattaller than average andsometimes have belownormal intelligence.Increased amounts of acneNormal sexual development