1. David J.A. Jenkins et al. JACC 2018;71:2570-2584
Forest Plot of Folic Acid Supplementation and Stroke Risk The diamond represents the pooled risk estimate. Interstudy heterogeneity was tested using the Cochran Q statistic (chi-square) at a significance level of p < 0.10 and quantified by the I2 statistic. The results show a RR of 0.80 in favor of folic acid. This 20% reduction in stroke risk was driven by the highly influential Chinese folic acid supplementation study, made in a community without folic acid fortification, but is the major supplement finding of the last 6 years. The number needed to treat (NNT) for folic acid supplementation and stroke risk is 167. df = degree of freedom; M-H = Manthel-Haenszel; other abbreviations as in Figure 2.
David J.A. Jenkins et al. JACC 2018;71:
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