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Volume 95, Issue 2, Pages 281-295 (February 2019)
Management and treatment of glomerular diseases (part 2): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Brad H. Rovin, Dawn J. Caster, Daniel C. Cattran, Keisha L. Gibson, Jonathan J. Hogan, Marcus J. Moeller, Dario Roccatello, Michael Cheung, David C. Wheeler, Wolfgang C. Winkelmayer, Jürgen Floege Sharon G. Adler, Charles E. Alpers, Isabelle Ayoub, Arvind Bagga, Sean J. Barbour, Jonathan Barratt, Daniel T.M. Chan, Anthony Chang, Jason Chon Jun Choo, H. Terence Cook, Rosanna Coppo, Fernando C. Fervenza, Agnes B. Fogo, Jonathan G. Fox, Richard J. Glassock, David Harris, Elisabeth M. Hodson, Jonathan J. Hogan, Elion Hoxha, Kunitoshi Iseki, J. Charles Jennette, Vivekanand Jha, David W. Johnson, Shinya Kaname, Ritsuko Katafuchi, A. Richard Kitching, Richard A. Lafayette, Philip K.T. Li, Adrian Liew, Jicheng Lv, Ana Malvar, Shoichi Maruyama, Juan Manuel Mejía-Vilet, Chi Chiu Mok, Patrick H. Nachman, Carla M. Nester, Eisei Noiri, Michelle M. O'Shaughnessy, Seza Özen, Samir M. Parikh, Hyeong- Cheon Park, Chen Au Peh, William F. Pendergraft, Matthew C. Pickering, Evangéline Pillebout, Jai Radhakrishnan, Manish Rathi, Pierre Ronco, William E. Smoyer, Sydney C.W. Tang, Vladimír Tesař, Joshua M. Thurman, Hernán Trimarchi, Marina Vivarelli, Giles D. Walters, Angela Yee-Moon Wang, Scott E. Wenderfer, Jack F.M. Wetzels Brad H. Rovin, Dawn J. Caster, Daniel C. Cattran, Keisha L. Gibson, Jonathan J. Hogan, Marcus J. Moeller, Dario Roccatello, Michael Cheung, David C. Wheeler, Wolfgang C. Winkelmayer, Jürgen Floege Sharon G. Adler, Charles E. Alpers, Isabelle Ayoub, Arvind Bagga, Sean J. Barbour, Jonathan Barratt, Daniel T.M. Chan, Anthony Chang, Jason Chon Jun Choo, H. Terence Cook, Rosanna Coppo, Fernando C. Fervenza, Agnes B. Fogo, Jonathan G. Fox, Richard J. Glassock, David Harris, Elisabeth M. Hodson, Jonathan J. Hogan, Elion Hoxha, Kunitoshi Iseki, J. Charles Jennette, Vivekanand Jha, David W. Johnson, Shinya Kaname, Ritsuko Katafuchi, A. Richard Kitching, Richard A. Lafayette, Philip K.T. Li, Adrian Liew, Jicheng Lv, Ana Malvar, Shoichi Maruyama, Juan Manuel Mejía-Vilet, Chi Chiu Mok, Patrick H. Nachman, Carla M. Nester, Eisei Noiri, Michelle M. O'Shaughnessy, Seza Özen, Samir M. Parikh, Hyeong-Cheon Park, Chen Au Peh, William F. Pendergraft, Matthew C. Pickering, Evangéline Pillebout, Jai Radhakrishnan, Manish Rathi, Pierre Ronco, William E. Smoyer, Sydney C.W. Tang, Vladimír Tesař, Joshua M. Thurman, Hernán Trimarchi, Marina Vivarelli, Giles D. Walters, Angela Yee-Moon Wang, Scott E. Wenderfer, Jack F.M. Wetzels Kidney International Volume 95, Issue 2, Pages (February 2019) DOI: /j.kint Copyright © 2019 The Author(s) Terms and Conditions
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Figure 1 Algorithm for refractory disease in lupus nephritis. APS, antiphospholipid syndrome; CNI, calcineurin inhibitor; CYC, cyclophosphamide; MMF, mycophenolate mofetil; TMA, thrombotic microangiopathy. Kidney International , DOI: ( /j.kint ) Copyright © 2019 The Author(s) Terms and Conditions
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Figure 2 Treatment algorithm for anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis. Remission is defined by the absence of manifestations of vasculitis and glomerulonephritis disease activity (Birmingham Vasculitis Activity Score for Wegner granulomatosis [BVAS/WG] of 0). For glomerulonephritis (GN), remission is considered as absence of microscopic hematuria and improved proteinuria and glomerular filtration rate. ∗Based on peripheral B-cell repopulation plus ANCA reappearance. †In patients with rapidly deteriorating kidney function, corticosteriods are often initiated i.v. as pulse doses of 500 to 1000 mg/d methylprednisone and given for 1 to 3 days before converting to an oral formulation. ‡Consider re-biopsy in order to guide second-line therapy. AZA, azathioprine; CYC, cyclophosphamide; PLEX, plasma exchange; PR3, proteinase 3; RTX, rituximab. Kidney International , DOI: ( /j.kint ) Copyright © 2019 The Author(s) Terms and Conditions
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